单中心临床Ⅰ期非精原细胞瘤10年诊治经验总结

Single-center ten-year experience of clinical stage Ⅰ nonseminoma

目的：探讨睾丸非精原细胞瘤（NSGCT）综合治疗的临床疗效以及辅助治疗方法。方法：回顾分析1999年5月~2008年12月近10年间在我院治疗的80例睾丸Ⅰ期NSGCT患者的临床资料,应用SPSS16.0统计软件包进行统计学分析,比较不同治疗方法与预后的关系。结果：生存分析显示腹膜后淋巴结清扫组与观察组差异有统计学意义（P=0.027）;化疗组预后较观察组好,腹膜后淋巴结清扫组与化疗组差异无统计学意义（P=0.660）。结论：临床Ⅰ期NSGCT在睾丸根治术后建议行腹膜后淋巴结清扫术,其次是辅助化疗;无高危复发因素、依从性好的患者可选择密切随访。

Objective：To explore the experience in the multitreatment of nonseminomatous germ cell tumor（NSGCT）of testis.Method：Clinical data of 80 patients with stageⅠ NSGCT of testis undergoing multi-disciplinary approach at Cancer Center of Sun Yat-Sen University were retrospectively analyzed from 1999 to 2008.The prognosis of different groups according to clinical stage was evaluated.The statistics modal is Kaplan-Meier methods.Result：There were 80 patients with stageⅠ nonseminoma.The disease-free survival in patients undergoing retroperitoneal lymph node dissection（RPLND）was higher than those surveillance（P=0.027）.The relapse-free survival curves of RPLND group and chemotherapy group had no significantly statistical difference（P=0.660）.Conclusion：The recommended treatment for stageⅠ nonseminoma after orchidectomy is RPLND and chemotherapy.Close surveillance is also a management option to patients without high risk of recurrence and with good compliance.