青少年高甘油三酯血症-腰围表型与心血管危险因素聚集相关

Relationship between hypertriglyceridemic-waist phenotype and clustering of cardiovascular risk factors in adolescents

目的：探讨高甘油三酯血症-腰围表型（HTWC）与心血管危险因素聚集的相关性。方法对秦皇岛地区一项3136名13～17岁汉族青少年作横断面调查。 HTWC 定义为腰围≥同年龄同性别青少年腰围的90百分位值且血甘油三酯≥1.47 mmol/ L 者。结果本调查人群中 HTWC 表型检出率为3.3%。甘油三酯和腰围正常组青少年心血管危险因素聚集者检出率为0.4%,而 HTWC 组青少年检出率为14.7%。校正性别、年龄、体重指数、糖尿病家族史和高血压家族史后,HTWC 组青少年心血管危险因素聚集检出率是甘油三酯和腰围正常组青少年的9.286（95% CI 3.161～27.282,P＜0.01）倍。结论 HTWC 表型与青少年心血管危险因素聚集密切相关,可做为识别青少年心血管危险因素的简单工具。

Objective The aim of the study was to explore the relationship between hypertriglyceridemic-waist（HTWC） phenotype and clustering of cardiovascular risk factors in adolescents. Methods A cross-sectional study was conducted in 3 136 Han adolescents aged 13-17 years in Qinhuangdao. The HTWC phenotype was defined as serum triglyceride concentrations ≥1. 47 mmol/ L and waist circumference ≥90 th percentile for age and sex. Results The prevalence of HTWC phenotype was 3. 3% . The prevalence of clustering of cardiovascular risk factors was 0. 4%in adolescents with normal waist circumference and serum triglyceride and 14. 7% in adolescents with HTWC phenotype. After adjustment for sex, age, body mass index, and family history of diabetes and hypertension, the prevalence of clustering of cardiovascular risk factors in adolescents with HTWC phenotype was 9. 286 fold（95% CI 3. 161-27. 282, P〈0. 01） of that in adolescents with normal waist circumference and triglyceride. Conclusion There was a significant correlation between HTWC phenotype and clustering of cardiovascular risk factors, suggesting that this phenotype may be applied as a simple marker for identifying adolescents with clustering of cardiovascular risk factors.