胰升糖素样肽1减少内质网应激的研究进展

Research progress in mitigation of endoplasmic reticulum stress by glucagon like peptide-1

胰升糖素样肽1（glucagon-like peptide-1, GLP-1）是一种经食物刺激后主要由回肠末端、结肠和直肠中 L 细胞产生和分泌的肠促胰岛素,它可以与体内 GLP-1受体结合,发挥一系列的生物学效应。近年来研究表明,GLP-1通过减少内质网应激,参与了多种疾病的发生及发展。

Glucagon-like peptide-1（GLP-1） is an incretin stimulated by food mainly produced and secreted from L-cells in terminal ileum, colon and rectum. It can be combined with GLP-1 receptors, and then plays a series of biological effects. In recent years, studies have shown that GLP-1 participates in the occurrence and development of many diseases.