XRCC4在结直肠癌组织中的表达与PETCT SUV值的相关性

Correlation between XRCC4 protein in colorectal cancer and SUV value of PETCT

目的探讨XRCC4(X-ray cross-complementing group 4)作为检测结直肠癌的新型肿瘤标志物的应用价值。方法收集术前行PETCT检查的结直肠癌患者的切除肿瘤组织21例,应用ELISA法检测肿瘤组织中XRCC4蛋白表达情况,并与术前PETCT的标准摄取值(SUV)相比对,进行相关性分析。结果肿瘤组织内XRCC4蛋白高表达,且与PETCT中SUV值密切相关(P<0.01)。结论 XRCC4蛋白作为新一代肿瘤标志物可能参与肿瘤细胞的能量代谢;结合PETCT检查,XRCC4蛋白可为结直肠癌的诊断与治疗提供一种新的思路。

Objective To study the application value of XRCC4 protein（X-ray crosscomplementing group 4）as a new colorectal cancer marker.Methods The expression of XRCC4 protein in 21 tumor tissue samples from the patients with colorectal cancer was detected by ELISA,who had PETCT examination before operation.The relationship between XRCC4 expression and the standard uptake value（SUV）of PETCT was analyzed.Results The expression of XRCC4 protein was significantly higher in the tumor tissues and closely related with the SUV value of PETCT（P〈0.01）.Conclusion XRCC4 protein as a new cancer marker may participate in the energy metabolism of colorectal cancer cells.Combined with PETCT examination,XRCC4 protein detection may provide a new clue in the diagnosis and treatment of colorectal cancer.