原虫抗肿瘤免疫机制研究进展

Progresses on Antitumor Immune Mechanisms of Protozoon

阿米巴原虫、克氏锥虫、艾美尔球虫、恶性疟原虫和刚地弓形虫等多种原虫可激活和调节人体免疫系统,改变肿瘤诱导的免疫抑制状态,增强机体抗肿瘤反应。本文对原虫抗肿瘤的细胞免疫、体液免疫和肿瘤微环境进行综述,旨在探讨其免疫机制,为原虫抗肿瘤的研究提供理论参考。

A variety of protozoons（Amoeba, Trypanosoma cruzi, Eimeria, Plasmodium falciparum and Toxoplasma gondii, etc.） can activate and regulate the human immune system, change tumor-induced immunosuppression, and enhance the anti-tumor immune response. This paper reviews the effects of protozoon on cellular and humoral immunity,the tumor microenvironment in tumor-bearing organisms, and reveals the antitumor immune mechanisms of protozoon.