C/EBPα和CK10在鼻腔鼻窦内翻性乳头状瘤中的表达及临床意义

Expression and significance of C/EBPα and CK10 in nasal inverted papilloma

目的:检测鼻腔鼻窦内翻性乳头状瘤(NIP)组织中CCAAT增强子结合蛋白α(C/EBPα)、CK10的表达,进一步探讨其在NIP发生、发展及复发中的作用。方法:应用免疫组织化学PV-6000二步法检测30例NIP组织、20例鼻息肉(NP)组织和10例正常鼻黏膜(NM)组织中C/EBPα、CK10的表达。结果:1NM、NP与NIP组织中C/EBPα、CK10的阳性表达均差异有统计学意义(均P<0.05);2单纯NIP组与不典型增生NIP组中C/EBPα、CK10的阳性表达差异有统计学意义(P<0.05);3复发NIP组与未复发NIP组中C/EBPα、CK10的阳性表达率差异有统计学意义(P<0.05);4NIP组中C/EBPα和CK10的表达呈正相关(r=0.578,P<0.01)。结论:C/EBPα、CK10在NIP上皮增殖与分化的调控中可能起了重要作用,C/EBP-α和CK10的高度表达可作为NIP复发的指标。

Objective：The expression of C/EBPα,CK10 in nasal inverted papilloma（NIP）were detected in the study.Further discussed their significance in genesia,development and recurrence of NIP.Method：Three groups including nasal cavity mucosae（NM 10cases）,nasal polyp（NP 20cases）and NIP（30cases）were selected in the study.Expretion of C/EBPα,CK10 were detected by immunohistochemisty PV-6000 method.Result：1 The different expression of C/EBPαand CK10 in the group of NM,NP and NIP was statistically significant（P0.05）.2The different expression of C/EBPα,CK10 in the group of benign NIP and NIP with atypical hyperplasia was statistically significant（P0.05）.3The different expression of C/EBPαand CK10 in the group of NIP with recurrence and NIP with no recurrence was statistically significant,P0.05,respectively.4Our result indicate that the relationship of C/EBPαand CK10（r=0.578,P0.01）was direct correlation.The difference was statistically significant.Conclusion：In conclusion,the present results describe C/EBPα,CK10 expression in NIP and their possible implication in the regulation of tumor growth and differentiation.C/EBPαand CK10 production may prove useful in terms of a prognostic marker for the recurrence in nasal inverted papilloma.