空腹血糖与糖化血红蛋白在不同性别和年龄间的差异

Differences of FPG and HbA1c in different genders and different ages

目的研究厦门地区不同年龄和性别人群空腹血糖（FPG）与糖化血红蛋白（HbA1c）水平的差异,并探讨该地区人群FPG、HbA1c水平与性别、年龄的关系。方法采用横断面研究方法,收集2013年1-12月符合要求的7 754例体检者,抽取静脉血分别检测FPG与HbA1c水平,分析不同性别和年龄组之间FPG、HbA1c水平的差异,以及FPG、HbA1c与性别、年龄的关系,并分析采用2010年美国糖尿病学会（ADA）糖尿病（DM）诊断标准的诊断结果。结果男性体检人群FPG与HbA1c水平均高于女性,比较差异均有统计学意义（P〈0.05）;不同性别人群的FPG、HbA1c水平均呈现随年龄增大而逐渐上升的趋势;相关性分析发现除18-30岁年龄组,其余年龄段的男性、女性及全部体检者HbA1c与FPG水平均呈明显的正相关。依据2010年ADA标准,DM患者及高危人群分别占10.83%和43.65%。结论厦门地区人群FPG、HbA1c水平与年龄、性别均相关,提示有必要建立不同的参考区间和DM诊断切点;且2010年ADA标准可识别出更多的DM患者及高危人群,尤其适合应用于体检筛查。

Objective To study the differences of fasting plasma glucose（FPG）and glycosylated hemoglobin A1c（HbA1c）in different genders and ages,and to investigate the relationship between FPG and HbA1 clevels with gender and age.Methods By adopting the cross-sectional study method.7 754 cases of physical examination meeting the requirements in our hospital from Jan.2013 to Dec.2013 were recruited into this study.The venous blood sample was collected for detecting FPG and HbA1 c.The differences of FPG and HbA1 clevels in different gender and age groups were analyzed and the relationship between FPG and HbA1 clevels with gender and age was analyzed.The diagnosis results by adopting the diabetes mellitus（DM）criteria of American Diabetes Association in 2010 was analyzed.Results The FPG and HbA1 clevels in the male physical examination individuals were significantly higher than those in females,the differences were statistically significant（P〈0.05）,moreover,the FPG and HbA1 clevels in different gender groups showed the gradually increasing trend with age increasing;The correlation analysis found that except for the 18-30 years old group,the HbA1 cand FPG levels in different age groups of males,females and the whole physical examination individuals showed the significant positive correlation.According to the criteria of ADA in2010,DM patients and high risk population accounted for 10.83% and 43.65% respectively.Conclusion The FPG and HbA1 clevels may be related with age and gender in Xiamen area,which indicating that it should be necessary to establish different reference intervals and DM diagnostic cut-off points;the criteria of ADA in 2010 could identify more DM patients and high-risk DM individuals,especially suitable for the physical examination screening.