血清CEA、CA19-9及铁蛋白联合检测在胰腺癌诊断中的价值

Value of combination detection of serum CEA,CA19-9 and ferritin in diagnosing pancreatic cancer

目的探究血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)及铁蛋白联合检测在胰腺癌诊断中的价值。方法选取2011年7月至2013年4月在漯河市中医院住院治疗且确诊的胰腺癌患者64例(胰腺癌组),另选取慢性胰腺炎患者36例(慢性胰腺炎组)及体检健康者42例(对照组),比较各组血清CEA、CA19-9及铁蛋白水平及其检测敏感性和特异性。结果胰腺癌患者血清CEA、CA19-9及铁蛋白的表达水平均高于慢性胰腺炎组和对照组,差异均有统计学意义(P<0.05);不同TNM分期胰腺癌患者血清CEA、CA19-9及铁蛋白表达水平比较差异均有统计学意义(P<0.05);生存期不你芋6个月的患者血清CEA、CA19-9及铁蛋白表达水平均低于生存期少于6个月的患者,比较差异均有统计学意义(P<0.05);血清CEA、CA19-9及铁蛋白联合检测的敏感性为87.2%,特异性为96.1%。结论血清CEA、CA19-9及铁蛋白联合检测对胰腺癌的诊断有着重要的参考价值。

Objective To investigate the value of the combination detection of serum CEA,CA19-9and ferritin in the diagnosis of pancreatic cancer.Methods 64 patients conducted pancreatic cancer（pancreatic caner group）,other 36 patients with chronic pancreatitis（chronic pancreatitis group）and 42 healthy persons conducted physical examination（control group）in our hospital from Jul.2011 to Apr.2013 were recruited for this study.Serum CEA,CA19-9and ferritin expression levels in each group and detection sensitivity and specificity were compared.Results The serum CEA,CA19-9and ferritin expression levels in the pancreatic cancer group were significantly higher than those in the chronic pancreatitis group and the control group,the differences had statistical significance（P〈0.05）;the serum CEA,CA19-9and ferritin expression levels had the statistical differences among different stages of TNM classification（P〈0.05）;the serum CEA,CA19-9and ferritin expression levels in the patients with the survival period ≥6months were lower than those in the patients with the survival period〈6months,the differences had statistical significance（P〈0.05）;the sensitivity and the specificity of the combination detection of CEA,CA19-9and ferritin were87.2% and 96.1% respectively.Conclusion The combination detection of serum CEA,CA19-9and ferritin could have important reference value for the diagnosis of pancreatic cancer.