2009年-2012年广州地区新生儿筛查可疑阳性未召回原因分析及对策

Countermeasures and analysis of unrecall factor for neonatal screening suspected positive in Guangzhou from 2009 to 2012

目的分析广州地区2009年-2012年新生儿疾病筛查可疑阳性未召回原因,总结召回经验,并提出相应处理对策,为进一步提高可疑阳性召回率提供科学依据方法对2009年-2012年广州市新生儿筛查中心新生儿筛查可疑阳性及未召回情况进行分析。结果广州市新生儿筛查中心2009年至2012年共筛查新生儿717 622例,其中PKU筛查阳性1192例,占0.17%,召回率为99.4%;TSH筛阳性4149例,占0.58%,召回率为98.3%。4年间筛查阳性召回率保持在98%以上,共有76例可疑阳性未召回,占1.42%。未召回的主要原因是联系方式错误,占79.0%,其次是居住地及联系方式变更,占19.7%。结论加大新生儿筛查的宣传力度,加强医务人员的相关培训,提高患者家属对疾病的认识,建立完善的三级筛查网络有利于提高筛查阳性召回率。

Objective：A analysis of unrecall factor for neonatal screening suspected positive in Guangzhou from 2009 to 2012. To summarize the recall experience of newborn disease screening and put forward the corresponding countermeasures,which will provide a scientific basis for further improve the suspicious positive recall rate. Methods：To review the result of newborn screening and unrecall in Guangzhou Neonatal Screening Center between 2009 and 2012 year and analyze the situation of newborn screening suspected positive and unrecall. Results：A total of 717 622 newborns were screened from 2000 to 2009 year and screening result showed that 1192（0.17%）cases were phenylketonuria（PKU）positive and 4149（0.58%）cases were Thyroid stimulating hormone（TSH）positive. The recall rate of PKU and TSH screening positive cases were 99.4%and 98.3%respectively.The recall rate of screening positive cases was above 98%in four years and 76 positive cases were missed eventually. Conclusion：Neonatal screeing is an effective measure for early diagnosis of PKU and congenital hypothyroidism（CH）. Enhancement of education to patients,enforcement of training to the medical stuff and,establishment of effective recall network,will improve screeing and recalling rate.