扩散张量成像对发育迟缓儿童脑白质的定量研究

Quantitative study of diffusion tensor imaging in white matter of developmental delay children

目的应用扩散张量成像（diffusion tensor imaging,DTI）技术评价常规MRI平扫正常的发育迟缓儿童脑白质损伤。方法选取12~36个月常规MRI平扫正常的20例发育迟缓儿童及20例同龄发育正常对照组儿童进行常规MRI平扫及DTI检查。分别测量4个浅部脑白质与5个深部脑白质感兴趣区（region of interest,ROI）的各向异性（fractional anisotropy,FA）值及平均扩散率（mean diffusivity,MD）值。结果发育迟缓组浅部脑白质FA值明显低于对照组（P〈0.05）,发育迟缓组浅部脑白质及深部脑白质胼胝体压部MD值高于正常对照组（P〈0.05）;发育迟缓组深部脑白质FA值与对照组比较差异无统计学意义。结论应用扩散张量成像FA值及MD值能早期定量诊断常规MR平扫正常的儿童脑白质发育迟缓。

Objective To observe the changes of white matter by using diffusion tensor imaging（DTI） in developmental delay children with normal routine MRI results.Methods Twenty patients（aged 12—36 months） with developmental delay and the twenty cases of monthold matched normal development children were studied by conventional MRI and DTI technology.Fractional anisotropy（FA） and mean diffusivity（MD） values were measured in five regions of deep white matter and four regions of shallow white matter.Comparison were made in FA and MD values of developmental normal and development delay children.Results FA value in shallow white matter of developmental delay children was lower than that of control group（P〈0.05）,MD values in shallow white matter and corpus callosum knee of developmental delay children was higher than that of control group（P〈0.05）.Conclusion DTI may quantify the injuries of white matter microstructure in developmental delay children with normal routine MRI results.