随机尿高香草酸/肌酐(HVA/Cr)检测用于神经母细胞瘤诊断的Meta分析

Meta-analysis on the Value of Homovanillic Acid/Creatinine(HVA/Cr) at Random Urine Collection in the Diagnosis of Neuroblastoma

[目的]评估随机尿高香草酸与肌酐比值（HVA/Cr）在神经母细胞瘤诊断中的价值。[方法]通过对Medline、EMbase、中国期刊全文数据库、中国科技期刊全文数据库、万方数据库进行系统检索,对尿HVA/Cr在神经母细胞瘤诊断中应用的文献进行Meta分析。[结果]神经母细胞瘤组随机尿HVA/Cr比值明显显高于健康对照组,差异有统计学意义。随机尿HVA/Cr用于诊断神经母细胞瘤的汇总敏感性为0.81（95%CI：0.76-0.85）,汇总特异性为0.97（95%CI：0.96-0.97）,汇总受试者工作特征曲线（SROC）曲线下面积（AUC）为0.9246。[结论 ]随机尿HVA/Cr用于诊断神经母细胞瘤的敏感性和特异性都较高,具有较高的诊断应用价值。

[Purposel To assess the value of homovanillic acid/creatiuine （HVA/Cr） at random urine collection for the diagnosis of neuroblastoma. [ Methods ] Database including CNKI, VIP Information,Wanfangdata, Medline and EMbase were searched,and literatures on the HVA/Cr in the diagnosis of neuroblastoma were analyzed by Meta-analysis. [Results] The level of HVMCr at random urine collection was significantly higher in the neuroblastoma patients than that in the control group. The pooled sensitivity and pooled specificity of HVA/Cr in the diagnosis of neuroblastoma were 0.81 （95%CI：0.76-0.85） and 0.97 （95%CI：0.96-0.97） respectively,and the area under the curve （AUC） of summary receiver operating characteristic （SROC） was 0.9246. [Conclusion] The sensitivity and specificity on HVA/Cr at random urine collection in the diagnosis of neuroblastoma are both at a high level. Thus, HVA/Cr is a good biomarker for diagnosis of neuroblastoma.