非霍奇金淋巴瘤中PTEN、VEGF表达水平及微血管密度的研究

Expressions of PTEN,VEGF and Microvessel Density in Non-Hodgkin's Lymphoma

[目的]研究非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)组织中PTEN、VEGF表达水平及微血管密度(microvessel density,MVD),分析它们之间的相关性。[方法]运用免疫组化方法检测NHL组织中PTEN、VEGF的表达水平及CD105标记的MVD,同时将反应性淋巴结增生(reactive lymphoid hyperplasia,RLH)病例作为对照。[结果]NHL中PTEN表达水平(31.5%)显著低于RLH组(70.0%)(P<0.05),而VEGF表达水平与MVD均显著高于RLH组(P<0.05);在不同病理分型和不同临床分期的NHL患者中,VEGF、PTEN和MVD的差异均有统计学意义(P均<0.05);PTEN与VEGF和MVD均呈负相关关系。[结论]NHL中PTEN表达的减低及VEGF表达的升高,可促进肿瘤血管新生,进而促进NHL的发展及转移。

[ Purpose ] To investigate the expressions of PTEN and VEGF and microvessel density （MVD） in non-Hodgkin＇s lymphoma （NHL）and to analyze the correlation among them. [Methods ] Immunohistochemistry was used to detect PTEN and VEGF expressions and MVD labeled by CD105 in NHL patients,and reactive lymphoid hyperplasia （RLH）group was set as a control. [Results] Expression of PTEN （31.5%） in NHL group was significantly lower than that in RLH group （70.0%）（P〈0.05）;while expression of VEGF and MVD in NHL group were both significantly higher than those in RLH group （P〈0.05）.There was significant difference of VEGF, PTEN or MVD in NHL patients with different pathological type or with different clincal stage （P〈0.05）.PTEN was negatively correlated with both VEGF and MVD. [Conclusion] Low expression of FInN and high expression of VEGF in NHL might promote angiogenesis, progression and metastasis of NHL.