时间延迟对基因调节回路中生物记忆影响研究

Influence of time delay on the memory in a gene regulatory circuit

生物记忆是广泛存在于各种生物子系统的一种重要的效应.基于一个双反馈的基因调节回路模型,采用数值模拟的方法研究了局部反馈中存在的时间延迟对生物记忆时间的影响.结果发现,小量的延迟能够很大地提高生物记忆时间.并且,生物记忆随延迟时间呈线性增加.这种增强模式与噪声对生物记忆时间的提高完全不同.延迟和噪声对生物记忆的提高可以进行相互的控制增强,但不会影响对方的增强模式.

Biological memory is a ubiquitous phenomenon, which could be found in a variety of biological subsystems. Based on a model of dual feedback gene regulatory circuit, in this paper we investigate the influence of time delay on memory time. The results show that the memory time is enhanced dramatically due to the existence of time delay, and the memory time increases linearly with increase of time delay. This enhancement pattern is completely different from that induced by noise. The raising of biological memory by time delay and noise can be controlled and reinforced mutually without affecting the reinforcement mode of opposite side.