摘要
目的：探讨不同类型的孤立性心房颤动（房颤）患者血浆高敏C反应蛋白（hs-CRP）与大内皮素-1（big ET-1）的水平差异以及二者之间的关系。方法：入选我院128例纽约心脏协会心功能分级Ⅰ～Ⅱ级、左心室射血分数〉50％的孤立性房颤患者，其中阵发性房颤患者（阵发性房颤组）83例，持续性房颤患者（持续性房颤组）45例，同时选择年龄、性别及病情与之相匹配的阵发性事上性心动过速患者82例作为对照组，测定血浆hs—CRP及higET-1浓度并进行统计学分析。结果：①两组房颤患者血浆hs—CRP及hig ET-1浓度均高于对照组，差异有统计学意义（P〈0．05）。②持续性房颤组血浆hs—CRP浓度高于阵发性房颤组，差异有统计学意义（P〈0．05）；持续性房颤组血浆higET-1浓度较阵发性房颤组有升高趋势，但差异无统计学意义（P〉0．05）。③在阵发性房颤组，血浆hs—CRP浓度与hig ET～1浓度呈正相关（s=0．563，P〈0．05）；在持续性房颤组，血浆hs—CRP浓度与hig ET-1浓度有相关性（P〈0．05），但相关性较弱，r值〈0．1。结论：孤立性房颤患者血浆hs—CRP及hig ET-1浓度增加，且持续性房颤患者升高明显；阵发性孤立性房颤患者的血浆hs-CRP浓度big ET-1浓度呈正相关。
Objective： To explore the relationship between different levels of plasma high-sensitivity C-reactive protein （hs-CRP） and big endothelin-1 （big ET-1） in patients with different type of lone atrial ifbrillation （AF）.
Methods： A total of 128 lone AF patients with NYHA 1 to NYHA 11 and LVEF 〉 50% were divided into 2 groups： Paroxysmal AF group, n=83 and Persistent AF group, n=45. There was a Control group, containing 82 patients of paroxysmal supra ventricular tachycardia with the matched age and gender. Plasma levels of hs-CRP, big ET-1 were examined and compared among different groups.
Results： （1） Compared with Control group, plasma levels of hs-CRP and big ET-1 were higher in both Paroxysmal and Persistent AF groups, P〈0.05. （2） Compared with Paroxysmal AF group, the patients in Persistent AF group showed the higher level of hs-CRP, P〈0.05, while the level of big ET-1 was similar between 2 AF groups, P〉0.05. （3） In Paroxysmal AF group, plasma level of hs-CRP was positively related to ET-1 （F0.563, P〈0.05）, and in Persistent AF group, hs-CRP was weakly related to ET-1 （r〈0. 1）.
Conclusion： Lone AF patients have elevated plasma levels of hs-CRP and big ET-1, such elevation is more obvious in persistent AF patients; plasma level of hs-CRP is positively related to big ET-1 in paroxysmal lone AF patients.
出处
《中国循环杂志》
CSCD
北大核心
2015年第3期240-243,共4页
Chinese Circulation Journal
