妊娠早期人微小病毒B19感染对孕妇血液系统的影响

The Influence of Human Parvovirus B19 Infection on the Blood System in Pregnant Women in Early Pregnancy

目的:探讨妊娠早期人微小病毒B19感染对孕妇血液系统的影响。方法:用酶联免疫吸附试验(ELISA)法检测60例早期自然流产患者(观察组)及同期自愿人工流产的健康早孕妇女60例(对照组)血清中HPVB19-Ig M的含量,检测两组孕妇血红蛋白、红细胞、白细胞及血小板计数并进行比较。结果:观察组、对照组人HPVB19-Ig M阳性患者血红蛋白和红细胞计数均低于阴性患者,差异有统计学意义(均P<0.05);观察组B19感染孕妇中贫血患病率53.85%(7/13)高于对照组21.28%(10/47),差异有统计学意义(P<0.05)。结论:人微小病毒B19感染对红细胞影响较明显,是病毒感染孕妇贫血的重要原因。

Objective：To investigate the influence on the blood svstem bv s human parvovirus B19 intection in pregnant women during early, Method：We identified 60 women who underwent early spontaneous abortion （observation group ） and 60 health controls who elected assisted abortion （ control group ）. The red blood cells, white blood cells and platetets were counted in each blood sample, the hemoglobin level was measured and the HPVB19 - IgM levels were determined by Enzyme linked immuno-sorbent test （ ELISA ）. Method： In both the observation and the control group, women positive with HPVB19IgM had lower hemoglobin and red blood cell count than women who are negative of the virus （ P 〈 0.05 for both）. Among the HPVB19 ＋ women, those in the observation group showed a higher anemia prevalence rate of 53.85 %（7/13） . compared to the control group （ 21.28% , 10/47 ）. The difference is statistically significant （ P 〈0.05 ）. Conclusion：There is a strongassociation between HPV B19 infection and red blood cell count, suggesting a causal effect of the infection on a- nemia.