摘要
目的：探讨大剂量红细胞生成素（rHuEPO）治疗慢性肾功能不全肾性贫血的临床效果。方法选取2011年10月-2013年8月本院收治的130例维持血液透析的慢性肾功能不全,具有尿毒症贫血的患者,将其随机分成两组,治疗组65例,采用剂量为10000 U/支的rHuEPO,皮下注射,1次/周。对照组65例,采用3000 U/支的rHuEPO,皮下注射,2-3次/周。比较两组的临床疗效,用药前后4、6、8、10、12周的Hct、Hb变化情况。结果治疗组的总有效率为96.9%,对照组为90.8%,治疗组的总有效率高于对照组（P〈0.05）。结论大剂量rHuEPO治疗慢性肾功能不全肾性贫血的效果显著,能够较快地提高Hb水平,纠正患者的贫血。
Objective To investigate the clinical effect of a large dose of erythropoietin （rHuEPO） treating renal anemia caused by chronic renal insufficiency. Methods 130 patients with chronic renal insufficiency and uremic anemia given maintenance hemodialysis were randomly divided into the two groups.The treatment group （n=65） was given a dose of rHuEPO with 10000 U for subcutaneous injection,once a week,while the control group （n=65） was given a dose of rHuEPO with 3000 U for subcutaneous injection twice or three times a week.The clinical efficacy and the change of Hct,Hb before medication after 4,6,8,10,12 weeks medication in the two groups were compared. Results The total effec-tive rate was 96.9%in the treatment group and the total effective rate was 90.8% in the control group,the total effective rate of the treatment group was higher than that of the control group （P〈0.05）. Conclusion A large dose of rHuEPO treating renal anemia caused by chronic renal insufficiency has a significant effect with higher safety,and can rapidly improve the level of Hb,and correct the anemia of patients.
出处
《中国当代医药》
2015年第7期136-138,共3页
China Modern Medicine
