吲达帕胺联合氨氯地平治疗高血压合并冠心病患者的疗效观察

Therapeutic effect of indapamide combined with amlodipine in treatment of patients with hypertension and coronary heart disease

目的：观察吲达帕胺联合苯磺酸左旋氨氯地平治疗高血压合并冠心病患者的临床疗效。方法将2012年1月~2013年12月在我院接受治疗的60例高血压合并冠心病患者，随机平均分为两组，观察组患者采用口服吲达帕胺缓释片联合苯磺酸氨氯地平片的方案进行治疗，对照组患者则口服硝苯地平缓释片进行治疗，观察并记录两组患者治疗前后的收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白等指标。结果两组患者经治疗后各指标均有改善，但观察组治疗后收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白等指标，与对照组相比较，差异具有显著性（P﹤0.05），且观察组明显优于对照组。结论吲达帕胺联合苯磺酸左旋氨氯地平可有效治疗高血压合并冠心病，临床疗效显著，在平稳降低血压的同时，更好的保护心脏功能，值得临床医生参考借鉴。

Objective To investigate the clinical efficacy of indapamide combined with levamlodipine besylate in patients with hypertension and coronary heart disease. Methods A total of 60 patients with hypertension and coronary heart disease who received treatment in our hospital from January 2012 to December 2013 were equally and randomly divided into observation group and control group. The observation group was orally given sustained-release tablets of indapamide combined with amlodipine besylate tablets, while the control group was orally given sustained-release tablets of nifedipine. The treatment outcomes of the two groups were evaluated based on systolic pressure, diastolic pressure, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein before and after treatment. Results After treatment, both groups had significant improvements in the above indices, but the observation group showed significantly more improvements compared with the control group （P﹤0.05）. Conclusion Indapamide combined with levamlodipine besylate is effective in treating hypertension and coronary heart disease. It has a significant clinical effect by stably reducing blood pressure to protect the cardiac function, so it holds promise for clinical application.