胺腆酮与美托洛尔联合应用与单用胺腆酮治疗阵发性心房纤颤的疗效观察

Therapeutic effects of amiodarone combined with metoprolol versus amiodarone alone in treatment of paroxysmal atrial fibrillation

目的探讨胺腆酮与美托洛尔联合应用与单用胺腆酮治疗阵发性心房纤颤的疗效观察。方法抽取2013年10月-2014年10月于我院就诊的阵发性心房纤颤患者共62例,将患者随机分为观察组(n=31)与常规组(n=31),常规组采用单纯胺碘酮治疗,观察组采用胺腆酮与美托洛尔联合治疗,观察两组患者的治疗效果。结果治疗后,观察组SBP、DBP、HR分别为(138.8±3.1)mm Hg、(95.2±8.5)mm Hg、(73.4±10.1)次/min,明显低于常规组(151.2±10.1)mm Hg、(130.2±10.8)mm Hg、(100.2±13.1)次/min,差异具有统计学意义(ta=6.535,tb=14.179,tc=9.021,P均小于0.05);观察组总有效率93.5%,明显高于常规组61.3%,差异具有统计学意义(χ2=7.473,P<0.05)。结论采用胺腆酮与美托洛尔联合治疗阵发性心房纤颤效果显著,能有效控制患者的血压及心率,值得临床大力推广。

Objective To investigate the therapeutic effects of amiodarone combined with metoprolol versus amiodarone alone in the treatment of paroxysmal atrial fibrillation. Methods Sixty-two patients with paroxysmal atrial fibrillation who were admitted to our hospital from October 2013 to October 2014 were equally and randomly divided into observation group and conventional group （31 cases for each group）. The conventional group was given amiodarone alone, while the observation group was given amiodarone combined with metoprolol. The treatment outcomes of patients in the two groups were observed. Results After treatment, the observation group had significantly lower systolic blood pressure （138.8±3.1mmHg vs 151.2±10.1mmHg, t=6.535, P﹤0.05）, diastolic blood pressure （95.2±8.5mmHg vs 130.2±10.8mmHg, t=14.179, P﹤0.05）, and heart rate （73.4±10.1beats/min vs 100.2±13.1beats/min, t=9.021, P﹤0.05） than the conventional group. The observation group had a significantly higher overall response rate than the conventional group （93.5% vs 61.3%,χ2=7.473, P﹤0.05）. Conclusion Amiodarone combined with metoprolol can effectively control the blood pressure and heart rate and has a significant therapeutic effect in the treatment of paroxysmal atrial fibrillation, so it holds promise for clinical application.