三氧化二砷及其磁性纳米复合体对骨肉瘤作用的实验研究

Effect of arsenic trioxide and its magnetic nanoparticles against osteosarcoma

目的:探讨三氧化二砷及其磁性纳米复合体对骨肉瘤的影响。方法:研究并比对了三氧化二砷、顺铂两种药物对骨肉瘤细胞MG-63的抑制作用,并制备磁性三氧化二砷-聚乳酸纳米粒子复合体,将其经尾静脉注入成骨肉瘤的裸鼠体内,与三氧化二砷、顺铂的疗效进行比较。结果:三氧化二砷可更有效地抑制MG-63细胞生长,引起细胞凋亡,并将细胞抑制于G1期。结论:磁性三氧化二砷纳米粒子可明显抑制裸小鼠骨肉瘤的生长,其可减少三氧化二砷的用量,从而减小毒副作用。

Objective： To investigate the effects of arsenic trioxide（ As2O3） and its magnetic nanoparticles on osteosarcoma. Methods： The inhibitory effects of As2O3 and cisplatin on osteosarcoma in cultured MG-63 cells were compared. Furthermore,the inhibitory effects of cisplatin,As2O3,and magnetic As2O3 nanoparticles on osteosarcoma in nude mice were compared. Results： As2O3 could effectively inhibit the growth of MG-63 cells and induce apoptosis in G1 phase. Conclusion： As2O3 nanoparticles can significantly inhibit the growth of osteosarcoma in nude mice,which can reduce the dosage and side effect of As2O3.