全脑放疗联合替莫唑胺化疗治疗非小细胞肺癌脑转移的疗效观察

Curative effect observation of temozolomide combined with whole brain radiotherapy in the brain metastases patients of non-small cell lung cancer

目的:探讨全脑放疗联合替莫唑胺化疗治疗非小细胞肺癌脑转移的毒副反应及疗效。方法:回顾性分析我院收治的44例非小细胞肺癌脑转移患者的资料。将44例患者按照治疗方案分为观察组和对照组,观察组采用全脑放疗联合替莫唑胺化疗,对照组仅采用全脑放疗,分析两组患者的毒副反应及近、远期疗效。结果:观察组和对照组消化道反应、血液学毒性、肝肾功能毒性等毒副反应比较,差异均无统计学意义(P>0.05);两组患者的近期疗效比较,客观有效率及局部控制有效率差异有统计学意义(P<0.05);两组患者6个月及1年的生存率比较差异有统计学意义(P<0.05)。结论:全脑放疗联合替莫唑胺化疗治疗非小细胞肺癌脑转移者有较好的近期疗效,并能提高患者的生存率。

Objective： To explore the efficacy and safety of temozolomide combined with whole brain radiotherapy in patients with brain metastases of non-small-cell lung cancer（ NSCLC）. Methods： 44 cases patients with brain metastases from non-small cell lung cancer were retrospectively analyzed. Patients were divided into observation group and control group. The observation group underwent whole brain radiotherapy plus temozolomide,control group received whole brain radiotherapy. The curative effect and adverse reactions of two groups were analyzed.Results： Such side effects like digestive reaction,hematology toxicity,liver and kidney function were observed and compared between the observation group and control group,there was no statistically significant difference（ P〉0. 05）. While the objective effectiveness and local controlling effectiveness had significant difference（ P〈0. 05）,as well as 6 months and 1 year survival rate（ P〈0. 05）. Conclusion： Temozolomide combined treatment with whole brain radiotherapy has a better curative effect in a short term in the brain metastases patients of non-small cell lung cancer,and it improves the survival rate of patients.