子痫前期患者血清sHLA-G和IL-10水平的检测及其意义

Serum sHLA-G and IL-10 levels study of preeclampsia

目的:测定子痫前期患者血清可溶性人类白细胞抗原G(s HLA-G)和白细胞介素-10(IL-10)水平,探讨其在子痫前期发生中的意义。方法:收集子痫前期患者35例、健康孕妇45例和健康未孕妇女38例的血清,酶联免疫吸附法检测s HLA-G和IL-10水平。结果:子痫前期患者血清s HLA-G和IL-10水平均明显低于正常妊娠孕中期组和孕晚期组(均P<0.05);s HLA-G水平高于健康未孕组,IL-10水平低于健康未孕组(均P<0.001)。结论:血清s HLA-G和IL-10水平在子痫前期发生时下降,对其检测有助于预测子痫前期的发生。

Objective： To explore the expression of soluble human leucocyte antigen G（ s HLA-G） and interlekin-10（ IL-10） in the serum of preeclampsia patients and their clinical significance in preeclampsia. Methods： Enzymelinked immunosorbent assay（ ELISA） was used to measure s HLA-G and IL-10 in the serum of 35 preeclampsia patients,45 healthy pregnant women and 38 healthy non-pregnant women and the results were analyzed. Results：The serum s HLA-G and IL-10 levels of preeclampsia patients were significantly lower than the second and the third trimester of pregnancy groups respectively,the differences were statistically significant respectively（ P〈0. 05）. The serum s HLA-G level of preeclampsia group was higher than healthy non-pregnant group,and the serum IL-10 level of preeclampsia group was lower than healthy non- pregnant group, the differences were statistically significant respectively（ P〈0. 001）. Conclusion： The s HLA-G and IL-10 in the serum are decreased when preeclampsia occurs,and the detection of s HLA-G and IL-10 are conducive to predict the occurrence of preeclampsia.