阿德福韦酯致Fanconi综合征6例并文献复习

Adefovir induced Fanconi syndrome: case report

目的:了解阿德福韦酯导致肾脏损伤的临床特点和预后。方法:报告6例小剂量阿德福韦酯导致Fanconi综合征的患者临床起病和肾损害特点、诊断以及预后。结合文献讨论长期应用阿德福韦酯时肾损害的合理监测和早期诊断。结果:长期小剂量服用阿德福韦酯可以导致Fanconi综合征,临床表现隐袭,容易延误诊断。如果及时停药,肾小管功能可以恢复。结论:应提高对于阿德福韦酯肾脏损害的认识,在患者服药过程中应加强随访,一旦发现肾脏受损应尽早干预。

Objective： To investigate the features of adefovir induced renal injury. Methods： We reported 6 cases of adefovir induced Fanconi syndrome. The onset of disease, the clinical characteristics and renal outcome were described. We further discussed the proper surveillance and early diagnosis of adefovir related renal injury. Results： Long-term use of adefovir at low dose can cause Fanconi syndrome. The onset of renal injury is usually insidious and tends to be delayed diagnosed. The tubular function can recover if adefovir is stopped timely. Conclusion： More attention should be paid to adefovir induced kidney injury.