蕈样霉菌病临床病理观察

Clinicopathologic study of mycosis fungoides

目的探讨蕈样霉菌病(MF)的临床及病理学特点。方法对2例蕈样霉菌病进行临床病理及免疫组化观察,并复习近期的相关文献。结果蕈样霉菌病组织学特征为真皮内具有脑回状细胞核的异型T淋巴细胞呈灶性、片状或弥漫性浸润,可累及皮下脂肪组织,可见亲表皮性及Pautrier微脓肿。免疫组化肿瘤细胞表达CD3、CD45RO、CD4。结论 MF是皮肤T细胞淋巴瘤,诊断主要依赖临床特点及病理组织学检查结果。

Objective To explore the clinicopathological characteristics of mycosis fungoides（ MF）. Methods Clinicopathological examination and immunohisto-chemical findings were analyzed in two cases of mycosis fungoides,and the recently related literature was reviewed. Results The pathological manifestations were focal,laminar or diffuse infiltration of atypical lymphocytes with cerebriform nuclei presented in dermis,and subcutaneous adipose tissue might also be involved. Epidermotropic lymphocytes or Pautrier＇s microabscesses were the typical histological features in MF. Immunohistochemically,tumor cells were positive for CD3,CD45 RO and CD4. Conclusion MF is cutaneous T cell lymphoma. Its diagnosis depends on histopathological and immunohistochemical findings.