家兔肝脏低剂量CT灌注成像的可行性研究

The feasibility study of hepatic low-dose CT perfusion imaging in rabbit

目的:探讨低剂量CT灌注成像对家兔肝脏灌注成像参数及图像质量的影响。方法:对9只家兔行常规剂量、中等剂量和低剂量肝脏CT灌注成像,对图像进行后处理,测量肝脏灌注参数值,包括肝血容量(BV)、肝血流量(BF)、肝动脉灌注量(APL),并对获得的肝脏灌注图进行主观质量评分,对3组灌注参数值和图像质量评分进行统计学分析。同时记录三种条件下的辐射记录值。结果:低剂量组、中等剂量组和常规剂量组的BF、BV、APL值差异无统计学意义(P>0.05)。低剂量组、中等剂量组和常规剂量组图像主观评分分别为(4.11±0.65)分、(4.38±0.61)分和(4.56±0.58)分,2名医师观察者间一致性较好(Kappa值为0.507)。低剂量组所接受辐射剂量远低于常规记录,容积CT剂量指数(volume CT dose index,CTDIvol)和剂量长度乘积(dose length product,DLP)均下降了75%。结论:基于降低管电流方式的家兔肝脏低剂量CT成像是可行的。

Objective：To explore the effect of hepatic lose-dose CT perfusion imaging for perfusion parameters and image qual- ity. Methods：9 rabbits were undergone routine dose, median dose and low-dose CT perfusion scanning. The original images were pro- cessed by perfusion software. The value of blood volume （BV） ,blood flow （BF） and arterial liver perfusion （ALP） were measured and image quality were evaluated, and statistical analysis was performed. Results： The differences of BF, BV, and ALP among the three groups were not statistically significant （ P 〉 0. 05 ）. The scores of image quality in routine dose group, median dose group and low-dose group were 4. 11 ±0. 65,4. 38 ± 0.61 and 4.56 ± 0. 58,respectively. The two reviewers keep good consistency. Kappa value of two re- viewers was 0. 507. Compared with the routine dose group,the value of CTDIvol and DLP of the low-dose group decreased 75%. Con- clusion：Low-dose hepatic CT perfusion imaging based on reducing tube current in rabbit was feasible.