糖耐量减低人群工作记忆的脑功能磁共振成像研究

A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique

目的探讨糖耐量减低的认知功能以及在特定任务刺激下不同脑区的活动情况。方法对13例糖耐量减低(impaired glucose tolerance,IGT)患者和19名糖耐量正常(normal glucose tolerance,NGT)受试者进行认知、记忆评估及词语(文字、数字)工作记忆及客体(面孔)工作记忆任务下的功能性磁共振检查,分析脑激活图。结果 1IGT患者的认知与NGT组相比,差异无统计学意义(t=0.459,P=0.635)。2与NGT组相比,IGT组在文字工作记忆中右侧颞叶、颞上回(brodmann area 22,BA22区)等脑区激活减弱(t=55.81,P=0.009);数字工作记忆中,右侧豆状核、壳核等脑区激活减弱(t=216.84,P=0.009);客体工作记忆中:右侧尾状核体激活减弱(t=5.09,P=0.008)。结论 IGT患者词语及客体工作记忆经典激活脑区可能存在损害。

Objective To investigate the working memory in the patients with impaired glucose tolerance（ IGT） by functional magnetic resonance imaging（ f MRI）. Methods Verbal and objective working memory tasks were performed in 13 patients with IGT and19 persons with normal glucose tolerance（ NGT） while performing f MRI. The cognitive function,memory function and the activation map were analyzed. Results 1 There was no significant difference in cognition function between the NGT and IGT group（ t = 0. 459,P =0. 635）. 2Compared with NGT group,there was less activation of right temporal and superior temporal gyrus（ BA22） area in IGT group during word working memory; less activation of right putamen,lenticular body in IGT group during number working memory; less activation of right caudate body in IGT group during object working memory（ P〈0. 01）. Conclusion IGT group may have lesions in the classic activation areas during verbal working memory and object memory.