小剂量生长激素治疗改善成人生长激素缺乏症及成人肥胖人群胰岛素敏感性的可能被引量：4

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摘要生长激素（GH）具有抗胰岛素（Ins）的作用,而其作用于肝脏产生的胰岛素样生长因子-1（IGF-1）却具有胰岛素样的性能.临床上,GH缺乏的成人和GH过度分泌所致的肢端肥大症患者都有胰岛素抵抗倾向,说明GH对Ins作用的影响非常复杂.过高或过低的GH水平导致胰岛素抵抗可能存在不同机制.随着近年来重组人生长激素（rhGH）在成人生长激素缺乏症（AGHD）患者的广泛应用,其在改善患者身体组分、骨密度、心血管危险因子等的同时,对胰岛素敏感性的影响也日益得到重视.有研究表明小剂量GH治疗可改善AGHD患者的胰岛素抵抗[1].本文将就rhGH治疗与胰岛素敏感性的关系做相关综述.

作者刘兆祥伍学焱

机构地区中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生和计划生育委员会内分泌重点实验室

出处《中华医学杂志》 CAS CSCD 北大核心 2015年第9期716-718,共3页 National Medical Journal of China

关键词生长激素缺乏症胰岛素敏感性激素治疗小剂量成人肥胖人群胰岛素样生长因子胰岛素抵抗

分类号 R587.1 [医药卫生—内分泌] R589.2 [医药卫生—内分泌]

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