胆管上皮细胞免疫功能的研究进展

Immune function of biliary epithelial cells

胆管上皮细胞(biliary epithelial cell,BEC),是衬复在胆管内的上皮细胞,他构成胆道系统对病原微生物的第一道防线.最新进展表明,BEC可以表达多种病原体识别受体,并能激活细胞内的信号转导通路,启动内在的抗病原微生物的防御系统,包括释放促炎细胞因子和趋化因子,合成抗菌肽和维护胆道上皮的完整性.BEC通过表达和释放细胞内的黏附分子和免疫介质与肝脏内的其他细胞(如淋巴细胞和枯否氏细胞)相互作用.他是一个涉及BEC和肝细胞的错综复杂的反馈机制,并调节BEC在微生物感染中的反应.因此,BEC积极参与胆道系统胆管黏膜免疫,构成了肝脏整体免疫的一部分.

Biliary epithelial cells （BECs） are the epithelial cells lining the bile duct, constituting the biliary system＇s first line of defense against pathogenic microorganisms. BECs can express many kinds of pathogen recognition receptors, activate intracellular signal transduction pathways, initiate the internal microbial defense system, including the release of pro- inflammatory cytokines and chemokines and antibacterial peptide synthesis, and maintain the integrity of the biliary epithelium. By expressing and releasing adhesion molecules and immune mediators, BECs interact withother cells in the liver, such as lymphocytes and Kupffer＇s cells. BECs are involved in a complex feedback mechanism of liver cells and thereby regulate the response to microbial infection. BECs actively participate in the biliary duct mucosal important component immunity and form an of liver immunity.