胆囊结石与胆囊癌局部浸润的关系

Relationship between gallstones and local invasion of gallbladder carcinoma

目的:探讨胆囊结石数量、直径、性质与胆囊癌局部进展的关系.方法:对经病理证实的150例胆囊癌进行回顾性分析,研究胆囊结石与胆囊癌Nevin分期的关系,并采用SPSS19.0统计软件处理,以χ2检验证实研究结果的统计学意义.结果:Nevin分期Ⅳ-Ⅴ期在结石组、多发结石组中、直径>2 cm组所占比例显著高于其对照组,统计学证实在结石组与无结石组、直径>2 cm组与<2 cm组2个对照组中的差异具有统计学意义(χ2=6.15、5.79,P<0.05),在多发结石组与单发结石组之间的差异无统计学意义(χ2=0.13,P>0.5).目前资料对胆囊结石具体数量、性质的统计较少,无法判断其与胆囊癌Nevin分期之间的关系,需进行更多的研究.结论:胆囊结石尤其直径>2 cm可导致胆囊癌局部进展更明显.提倡预防性胆囊切除术.

AIM： To explore the relationship between the local invasion of gallbladder carcinoma and the features of gallstones, such as quantity and diameter. METHODS： One hundred fifty patients with pathologically confirmed gallbladder carcinoma were analyzed. The relationship between gallstones and the Nevin stage of gallbladdercarcinoma was analyzed RESULTS： Stages IV and V gallbladder carcinoma was more commonly seen in patients with gallbladder stones （x2 = 6.15, P 〈 0.05）, especially those with stones greater than 2 cm in diameter （x2 = 5.79, P 〈 0.05）. However, the number of stones （single or multiple） showed no significant correlation with the Nevin stage of gallbladder carcinoma （x2 = 0.13, P 〉 0.05）. CONCLUSION： Gallbladder carcinoma patients with gallbladder stones, especially those greater than 2 cm in diameter, tend to have a more serious disease.