鱼腥草联合bFGF眼液治疗屈光手术后干眼的疗效观察

Clinical effect of houttuynia cordata eyedrops combined with bFGF eyedrops in treating dry eye after keratorefractive surgery

目的:观察鱼腥草联合碱性成纤维细胞生长因子(bFGF)眼液治疗屈光手术后干眼的临床疗效。方法:屈光手术后复查并诊断干眼症的患者117例204眼,随机分为对照组56例91眼和治疗组61例113眼,对照组给予bFGF眼液滴眼,治疗组给予鱼腥草滴眼液联合bFGF眼液滴眼。治疗2wk和4wk后观察疗效:进行干眼症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SchirmerⅠ)及角膜荧光素染色试验检测。结果:治疗2wk和4wk后两组干眼指标均有改善,自觉症状评分、BUT、Schirmer I、角膜荧光素染色结果组间比较,治疗组疗效明显优于对照组,差异均有统计学意义(P<0.05),4wk后治疗组总有效率98%,对照组总有效率90%,差异有统计学意义(P=0.011)。

AIM： To observe the clinical effect of houttuynia cordata eyedrops combined with basic fibroblast growth factor（ bFGF） eyedrops in treating dry eye after keratorefractive surgery.METHODS： Respectively,117 patients（ 204 eyes） were randomly assigned to treatment group（ 61 patients,113eyes） andthe control group（ 56 patients,91 eyes）. In control group,the eyes were used bFGF eyedrops four times a day,one drop at a time,and the treatment group was used bFGF eyedrops and houttuynia cordata eyedrops. After 2wk and 4wk of treatment, clinic symptom,Shirmer Ⅰ test（ SⅠt）,break- up time of tear film（ BUT） and fluorescence staining were recorded respectively.RESULTS： After 2wk and 4wk of observation,the clinic symptom of two groups was both improved. SⅠ t,BUT and fluorescence staining scores in the treatment group were significantly better than those in control group（ P〈0. 05）. After 4wk,the total effective rate of treatment group was 98%,while that in the control group was 90%,there was significant difference between the two groups（ P =0. 011）.CONCLUSION： Houttuynia cordata eyedrops can improve the effect of bFGF eyedrops in treating dry eye after keratorefractive surgery.