超声监测肝豆状核变性患者肝脾动脉血流动力学指标及其临床意义

Evaluation of hemodynamics in hepatic and splenic artery of patients with hepatolenticular degeneration and its clinical value by ultrasonography

目的:利用彩色多普勒超声对肝豆状核变性患者的右肝动脉、脾门处脾动脉的血流动力学指标进行监测,探讨在病程的不同阶段,二者是否存在相关性以及其临床意义。方法:选取40例正常人为对照组(A组),40例肝豆状核变性不合并脾大的患者(B组)和40例肝豆状核变性合并脾大的患者(C组)为患者组。应用彩色多普勒超声技术对A、B、C组在空腹状态下的右肝动脉及脾门处脾动脉最大血流速度进行探测。利用统计学软件分析组间血流动力学指标的变化差异是否有统计学意义,并对二者间的变化趋势行Spearman相关性分析。结果:随着脾大程度的不断进展,右肝动脉的血流速度呈下降趋势,脾门处脾动脉的血流速度呈上升趋势,且二者血流变化具有一定的相关性(rs=-0.837,P=0.039)。结论:随着病情进展,脾动脉血流速度升高的同时,肝动脉的血流速度下降,且二者间变化有一定的相关性,可为临床对病情的监测及后期治疗提供参考。

Objective：To evaluate the hemodynamics in right hepatic artery and splenic artery of patients with hepatolenticular degeneration（HLD） by ultrasound,and to study the correlation between them and its clinical value in different phases. Methods：40 healthy subjects were sampled as control group（group A）,40 cases with HLD as group B,40 cases with HLD and splenomegaly as group C. The maximal blood flow speed of right hepatic artery and splenic artery at splenic hilum were detected in all subjects in fasting condition by ultrasound. Analysis on changes of hemodynamics between each group were made by the sta-tistics software,and the trend of changes underwent Spearman test. Results：With the increase of splenomegaly degree,blood flow speed of the right hepatic artery showed a descending trend,but of the splenic artery at splenic hilum showed a rising trend.And there was a correlation between the trends（rs =-0.837,P =0.039）. Conclusions：With the progression of the disease,blood flow speed of the splenic artery at splenic hilum has a rising trend,while that of the right hepatic artery has a descending trend,and there is a correlation between the two trends. It offers a referenced value for the assessment of clinical state and the es-tablishment of the therapeutic schedule.