氧化应激和骨代谢水平与老年原发性骨质疏松症间的相互关系

The relationship between oxidative stress and bone turnover in the elder people with Osteoporosis

目的探讨氧化应激、骨代谢水平与老年原发性骨质疏松症间的相互关系。方法回顾性分析2012年5月至2013年12月间,我院体检的老年患者共62例,平均年龄为72.39岁（62～92岁）,其中男性30例,女性32例,根据BMD结果分为骨量正常组14例,骨量减少组19例,骨质疏松组29例。所有患者均抽取外周血,检测AOPP、SOD、β-CTX和tP INP水平。应用SPSS10.0对3组的数据进行比较分析。结果骨质疏松组中血清AOPP高于骨量减少组和骨量正常组,SOD水平则在骨质疏松组中最低（P〈0.05）。各组间β-CTX和tP INP水平无统计学差异。相关性检测提示AOPP与BMD（r=-0.59,P〈0.00）、SOD（r=-0.58,P〈0.00）呈负相关,与β-CTX（r=-0.31,P〈0.02）、年龄（r=0.53,P〈0.00）呈正相关。同时,为明确各指标对BMD的影响,采用线性回归方程分析后发现,血清AOPP和SOD水平对BMD影响较大。结论氧化应激可引起骨代谢紊乱,主要表现为骨破坏增加,可影响老年患者BMD,对老年原发性骨质疏松症的发生和发展有重要影响,抗氧化治疗可能对该病有一定的疗效。

Objective To evaluate the relationship between oxidative stress and bone turnover in the elderly with osteoporosis.Methods A retrospective study was conducted from May 2012 to December 2013.We included 62 cases of elder women（n =32） and men（n =30）,with an average age of 72.39 years（62-92 years）.There were divided to normal bone mass group（n =14）,osteopenia group（n = 19）,and osteoporosis group（n =29）,according to the results of BMD.The blood levels of AOPP,SOD,β-CTX,and tPINP were examined and compared among the three groups using a SPSS 10.0 software.Results The AOPP level in osteoporosis group was higher than that in normal bone mass group and osteopenia group.Meanwhile,the SOD level was the lowest in osteoporosis group（P〈0.05）.There was no statistical difference among the 3 groups in the values of β-CTX and tPINP.AOPP was negatively correlated with BMD（r =-0.59,P〈0.00） and SOD（r =-0.58,P〈0.00）.On the contrary,AOPP was positively correlated with（3- CTX（r = 0.31,P〈0.02） and age（r = 0.53,P〈0.00）.Importantly,multiple regression analysis revealed that AOPP and SOD were determinant factors to BMD.Conclusion Oxidative stress can cause the disorder of bone metabolism,which is characterized by increasing of bone destruction that affects BMD.It plays an important role in the occurrence and development of osteoporosis in elderly people.Antioxidant therapy may have a certain effect on the disease.