不同腮腺症状原发性舍格伦综合征的血清学分析

The Correlation between Serological Profiles and Clinical Features of Parotid Glands in Primary Sjgren's Syndrome

目的:研究不同腮腺症状的原发性舍格伦综合征(primary Sj觟gren’s syndrome,p SS)患者之间的血清学特征的差异性。方法:回顾性研究289名患者,均符合原发性舍格伦综合征(2002年修订的欧美联合诊断标准)。依据患者腮腺的临床特征,将患者分为以下4组:第1组(类肿瘤组)、第2组(感染组)、第3组(肿大组)、第4组(口干组)。对比各组之间的人口统计学和血清学特征。每两组之间结果的统计学分析用t检验,F检验,卡方检验,方差分析。结果:不同的腮腺临床特征的p SS患者具有不同的血清学表型。第1组的血清免疫球蛋白Ig G值是4组中最高的,而补体C4是4组中最低的。第2组的血清免疫球蛋白Ig E值是4组中最高的。第3组的血沉值是4组中最高的。结论 :不同腮腺临床症状的p SS患者具有不同的血清学表型。这可能有助于增进我们对该疾病的认识。

Objective： To investigate the differences of serological profiles in primary SjOgren＇ s Syndrome （pSS） and eval- uate their correlation with the clinical characteristics of parotid glands. Methods： The retrospective study included 289 patients who fulfilled the diagnosis for pSS adviced by American-European Consensus Group Criteria in 2002. The patients were categorized by the clinical features of parotid glands： groupl （massive group）, group 2 （infection group）, group 3 （swelling group） and group 4 （others）. The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher＇s exact test, chi-square and analysis of variance. Results： There was differences of serological profiles in accordance with the different clinical characteristics of parotid glands of pSS patients. Serum IgG value in Group 1 was the greatest, and complement C4 was lowest in four groups. Serum IgE value in Group 2 was the greatest and ESR in Group 3 was the greatest among the four groups. Conclusion： This study demonstrates the differences of serological profile in different clinical features of parotid glands of ~SS patients, which may be benefit to advance our understanding of the disease.