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自身免疫性硬化性胆管炎:新概念与新证据 被引量：4

Autoimmune sclerosing cholangitis: new concept and new evidence
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摘要 硬化性胆管炎根据其病因及发病机制不同可分为原发性硬化性胆管炎(PSC)和继发性硬化性胆管炎,其中PSC的发病可能与免疫相关。近些年,新发现了一种硬化性胆管炎,以血清及组织免疫球蛋白(Ig)G4水平升高为特征,对激素治疗效果良好。PSC和Ig G4相关硬化性胆管炎可统称为自身免疫性硬化性胆管炎,在新概念中探索多种表现为硬化性胆管炎疾病间的同与异,更有助于拓展免疫相关性疾病的新思路与方向。 Sclerosing cholangitis can be divided into primary sclerosing cholangitis （PSC） and secondary sclerosing cholangitis according to the etiology and pathogenesis, and the pathogenesis of PSC may be associated with immunity. In recent years, a new type of sclerosing cholangitis has been found, which is characteristic of elevated levels of IgG4 in serum and tissue and good response to steroid therapy. PSC and IgG4 -related sclerosing cholangitis can be collectively referred to as autoimmune sclerosing cholangitis. This article explores the simi- larities and differences between various diseases with manifestations of sclerosing cholangitis in the new concept, which will provide new ide- as and directions for immune - related diseases.
作者 韩英 朱疆依
机构地区 第四军医大学第一附属医院消化内科
出处 《临床肝胆病杂志》 CAS 2015年第2期171-173,共3页 Journal of Clinical Hepatology
关键词 胆管炎 硬化性 自身免疫疾病 免疫球蛋白G cholangitits, sclerosing autoimmune diseases immunoglobulin G
分类号 R575.7 [医药卫生—消化系统]
  • 相关文献

参考文献17

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同被引文献49

  • 1Beuers U, Maillette De Buy Wenniger LJ, Doorenspleet M, et al. lgG4-associated cholangitis. Dig Dis, 2014,32(5):605-608.
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  • 3Kim JH, Byun JH, Lee SJ, et al. Differential diagnosis of scle- rosing cholangitis with autoimmune panereatitis and periductal in- filtrating cancer in the common bile duet at dynamic CT, endo- scopic retrograde cholangiography and MR cholangiography. Eur Radiol, 2012,22( 11 ) :2502-2513.
  • 4Okazaki K, Uchida K, Koyabu MA, et al. IgG4 cholangiopa- thy--Current concept, diagnosis, and pathogenesis. J Hepatol, 2014,61(3) :690-695.
  • 5Graham RP, Smyrk TC, Chari ST, et al. Isolated IgO4-related sclerosing cholangitis: A report of 9 cases. Hum Pathol, 2014,45 (8) : 1722-1729.
  • 6Zen Y, Nakanuma Y, Portmann B. Immunoglobulin G4 related sclerosing cholangitis: Pathologic features and histologic mimics. Semin Diagn Pathol, 2012,29(4) :205-211.
  • 7Hirano K, Tada M, Isayama H, et al. Endoscopic evaluation of factors contributing to intrapancreatic biliary stricture in autoim mune panereatitis. Gastrointest Endosc, 2010,71 ( 1 ) : 85-90.
  • 8Naitoh I, Nakazawa T, Ohara H, et al. Endoscopic transpapil lary [ntraduetal ultrasonography and biopsy in the diagnosis of IgG4-related selerosing cholangitis. J Gastroenterol, 2009, 44 (11) :1147-1155.
  • 9Arikawa S, Uehida M, Kunou Y, et al. Comparison of sc/eros- ing cholangitis with autoimmune pancreatitis and infiltrative ex- trahepatie holangiocarcinoma: Multidetector-row computed tomography findings. Jpn J RadioI, 2010,28(3):205-213.
  • 10You MW, Kim JH, Byun JH, et al. Relapse of IgG4-related sclerosing cholangitis alter steroid therapy: Image findings and risk factors. Eur Radiol, 2014,24(5) :1039-1048.

引证文献4

二级引证文献17

临床肝胆病杂志
2015年 第2期

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