CD44v3和CD44v5在口腔黏液表皮样癌中的表达及临床意义

Expression and clinical significance of CD44v3 and CD44v5 in oral mucoepidermoid carcinoma

目的:通过检测细胞表面黏附分子CD44v3和CD44v5在口腔黏液表皮样癌(Oral mucoepidermoid carcinoma,OMC)中的表达,探讨二者与OMC的发生、病理分级和临床分期的关系。方法:利用免疫组织化学方法检测40例OMC石蜡标本中CD44v3和CD44v5蛋白表达,并且分组进行统计学分析。结果:CD44v3和CD44v5在OMC中表达率与正常对照组相比有显著升高(P<0.05),不同病理分级、临床分期之间并无显著性差异(P>0.05)。结论:在OMC的淋巴结转移中,CD44v3和CD44v5可能起着重要作用,CD44v3、CD44v5可能成为了解OMC病变发生发展生物学行为及淋巴结转移重要的生物学指标之一。

Objective To detect the expression of the cell surface adhesion molecule CD44v3 and CD44v5 in oral mucoepidermoid carcinoma（OMC）,and to explore the relationship between the two and the occurrence,pathological grade and clinical stage of OMC. Methods Immunohistochemical staining was used to detect the exprssion of CD44v3 and CD44v5 protein in 40 cases of OMC in paraffin embedded specimens, and were statistically analyzed. Results CD44v3 and CD44v5 expression rates in OMC compared with the control group was significantly higher（P 0.05）, no significant differences between pathological grade, and clinical stage（P0.05）. Conclusion OMC in the lymph node metastasis,CD44v3 and CD44v5 may play an important role,CD44v3,CD44v5 may be one of the important indexesto understand the transfer of OMC lesion development and the biological behavior of lymph node.