肝内胆管癌中ErbB4的表达及临床意义

ErbB4 expression in intrahepatic cholangiocarcinoma and its clinical significance

目的:探讨表皮生长因子受体Erb B4在人肝内胆管癌(ICC)组织中的表达及意义。方法:采用免疫组化法分别检测24例ICC患者癌组织(ICC组)、癌旁胆管组织(癌旁组)及16例肝内胆管结石患者胆管组织(结石组)中Erb B4的表达,并分析Erb B4表达与ICC患者临床病理因素的关系。结果:Erb B4的强阳性表达率在ICC组中为75.0%,明显高于癌旁组(45.8%)和结石组(37.5%)(均P<0.05);且ICC组胞核Erb B4阳性表达率高于另两组(均P<0.05),而胞膜与胞质Erb B4阳性表达率3组间差异无统计学意义(均P>0.05)。Erb B4的高表达与ICC患者淋巴结转移及TNM分期有关(均P<0.05)。结论:Erb B4的表达增高与核内移与ICC的发生发展以及浸润转移密切相关。

Objective： To investigate the expression of epidermal growth factor receptor Erb B4 in human intrahepatic cholangiocarcinoma（ICC） tissues and its significance. Methods： The ErbB 4 expressions in 24 paired specimens of ICC tissue（ICC group） and adjacent bile duct tissue（tumor adjacent group）, and 16 specimens of bile duct tissue from hepatolithiasis patients（hepatolithiasis group） were detected by immunohistochemical staining, and the relations of ErbB 4 expression with the clinicopathologic factors of ICC patients were also analyzed.Results： The strong positive expression rate of ErbB 4 in ICC group was 75.0%, which was significantly higher than that in tumor adjacent group（45.8%） or hepatolithiasis group（37.5%）（both P〈0.05）, nuclear expression rate of ErbB 4 in ICC group was significantly higher than that in the other two groups（both P〈0.05）, while the membranous and cytoplasmic expression rates of ErbB 4 showed no significant difference among the three groups（both P〉0.05）. High ErbB 4 expression was significantly associated with lymph node metastasis and TNM stage of ICC patients（both P〈0.05）.Conclusion： Increased expression of Erb B4 and its transfer into cellular nucleus are closely related to the occurrence and development as well as infiltration and metastasis of ICC.