摘要
目的:探讨自体外周血造血干细胞移植(autologous peripheral blood stem cell transplantation,APBSCT)治疗非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)的临床疗效。方法:回顾性分析2009年2月至2013年10月在我院行APBSCT的NHL患者56例,其中男37例,女19例,中位年龄44岁(16~69)岁,缓解病例46例,部分缓解7例,复发难治3例。结果:56例移植患者中55例获造血重建,1例未造血重建。中性粒细胞绝对值〉0.5×109个/L的中位时间9.5 d(7~18 d)、血小板计数〉20×109个/L的中位时间11.5 d(6~24 d)。24例患者于粒细胞缺乏期时出现发热,5例出现轻中度腹泻,1例出现轻度肝功能损害,1例出现带状疱疹。所有患者随访截止于2014年4月1日,中位随访时间20.25月(3.0~60.5月)。45例存活(其中5例带病生存),10例复发,11例死亡(其中5例死于复发)。复发率为17.9%,总生存率(overall survival,OS)、无病生存率(disease free survival,DFS)分别为80.4%、71.4%。结论:APBSCT是治疗NHL的有效手段,造血重建快,并发症少。
Objective:To study the clinical efficacy of autologous peripheral blood hematopoietic stem cell transplantation(APBSCT)in the treatment of non-Hodgkin’s lymphoma(NHL). Methods:A total of 56 patients who underwent APBSCT from February 2009 toOctober 2013 in the hospital were enrolled in the study. There were 37 males and 19 females with a median age of 44 years(16-69 years);46 cases were in remission,7 cases in partial remission and 3 cases in relapsed or refractory. Results:Among56 patients treated by APBSCT,55 patients obtained hematopoietic reconstitution. The median time for neutrophils recovery(〉0.5×109/L)was 9.5(7-18)d and platelet recovery(〉20×109/L) was 11.5(6-24) d. Twenty-four patients experienced fever during granulocyte lack phase,5 patients experiencedmild-to-moderate diarrhea,one patient had mild liver function damage and one patient had herpes zoster. All patients were followed up till the 1st April,2014,and the median follow-up time was 20.25(3-60.5)months. Forty-five cases survived(5 cases alive with disease);10 cases relapsed;11 cases died(5 cases died of recurrence). The recurrence rate was 17.9%. Overall survival and diseasefree survival were 80.4% and 71.4% respectively. Conclusion:With the advantages of quicker hematopoietic reconstruction and fewer non-Hodgkin’s lymphoma,APBSCT is effective in the treatment of NHL.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2015年第1期154-158,共5页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81250034)
重庆市卫生局资助项目(编号:2013-2-023)
重庆市教委资助项目(编号:2013)
关键词
造血干细胞移植
自体
非霍奇金淋巴瘤
hematopoietic stem cell transplantation
autologous
non-Hodgkin’s lymphoma