Pokemon和p53在乳腺癌组织中的表达及其生物学意义

Expression of Pokemon and p53 in breast cancer and its biological significance

目的探讨乳腺癌组织中Pokemon和p53蛋白的表达及其相关性,并分析其与乳腺癌患者临床病理特征的关系。方法采用免疫组化En Vision法检测90例乳腺癌和相应癌旁组织中Pokemon和p53蛋白的表达情况。结果乳腺癌组织中Pokemon和p53蛋白表达阳性率均明显高于癌旁组织(均P<0.01);Pokemon和p53蛋白的表达与乳腺癌患者临床分期及淋巴结转移均有关(均P<0.01),而与患者年龄、肿瘤大小、组织学类型及分级均无关(均P>0.05)。Spearman相关分析显示在乳腺癌组织中,Pokemon和p53蛋白表达呈正相关(P<0.01)。结论Pokemon和p53蛋白异常表达可能与乳腺癌的发生、发展有关,联合检测两者对评估乳腺癌生物学行为及预后具有较重要的临床意义。

Objective To investigate the expression of Pokemon and p53 in breast cancer and its clinicopathologic significance. Methods The expression of Pokemon and p53 was detected in 90 cases of breast cancer and pericancerous breast tissues by En Vision immunohistochemical method. Results The positive rates of Pokemon and p53 in cancer tissue was significantly higher than those in pericancerous breast tissue （P〈0.01）. The expression of Pokemon and p53 proteins was corre-lated with clinical stage and lymph node metastasis （P〈0.01）;but not correlated with age, tumor size, histological types and clin-ical grades（P〉0.05）. Spearman correlation analysis showed that there was a positive correlation between Pokemon and p53 ex-pression in breast cancer （P〈0.01）. Conclusion Pokemon and p53 proteins are highly expressed in breast cancer, which may be associated with its biological behavior and prognosis of patients.