电针结合养血润肠颗粒剂治疗慢传输型便秘的临床研究

Clinical research of electro acupuncture combined with dispensing granule decoction of Enriching the Blood and Moisturizing the Intestine Granules in the treatment of slow transit constipation

目的观察电针结合养血润肠颗粒剂用于治疗慢传输型便秘的临床效果。方法选择中国中医科学院广安门医院2013年1~12月收治的90例慢传输型便秘患者,将其随机分为三组,分别为A、B、C组,各30例,分别给予电针结合养血润肠颗粒剂治疗、电针结合乳果糖口服液及单纯电针治疗,疗程20 d,统计并比较：1总有效率;2总积分及各主要症状积分;3结肠传输试验情况。结果 1A组总有效率为93.3%,B组为90.0%,C组为86.6%,三组比较差异有统计学意义（P〈0.05）。2治疗后和随访时三组总积分及各主要症状积分均较治疗前显著下降,差异有高度统计学意义（P〈0.01）。治疗后A组总积分为（4.23±3.45）分,显著低于B组[（5.56±3.02）分,P〈0.05]及C组[（6.33±3.09）分,P〈0.01]。随访时A组总积分为（4.70±2.75）分,显著低于B组[（7.80±3.85）分]和C组[（9.13±3.30）分]（P〈0.01）。3治疗后和随访时三组标志物数量均有所下降,差异有统计学意义（P〈0.05）。治疗后A组标志物为（4.38±1.36）枚,显著少于B组[（5.36±1.75）枚]和C组[（4.79±1.55）枚]（P〈0.05）。随访时A组标志物为（4.55±2.11）枚,显著少于B组[（7.44±3.67）枚]和C组[（9.52±6.38）枚]（P〈0.05）。结论电针结合养血润肠颗粒剂治疗慢传输型便秘效果满意,值得在临床上推广应用。

Objective To investigate the clinical curative effect of dispensing granule decoction of Enriching the Blood and Moisturizing the Intestine Granules combined with electro acupuncture in the treatment of slow transit constipation（STC）. Methods Ninety cases of patients with STC admitted to Guang＇anmen Hospital, China Academy of Chinese Medical Sciences from January to December 2013 were randomly divided into group A, B and C, with 30 cases in each group. The group A was treated with dispensing granule decoction of Enriching the Blood and Moisturizing the Intestine Granules combined with electro acupuncture, and the group B was treated with Lactulose Oral Solution with electro acupuncture, and the group C was treated with electro acupuncture treatment only. After treatment for 20 days, the indexes were observed and compared： 1 the total efficiency; 2 the overall symptom scores and the respective scores of each symptom of three groups; 3 the change of colonic transit test. Results 1 The total effective rate of the group A was 93.3%, while that of the group B was 90.0% and the group C was 86.6%, the difference among three groups was significant（P〈0.05）. 2The overall symptom scores and the respective scores of each symptom of three groups after treatment and during the follow-up decreased significantly compared with before treatment, the differences were statistically significant（P〈0.01）. The total effective rate of group A after treatment was（4.23 ±3.45） points, which was significantly lower than that of group B [（5.56±3.02） points, P〈0.05] and group C [（6.33±3.09） points, P〈0.01]. During the follow-up, the total effective rate of the group A was（4.70±2.75） points, which was significantly lower than that of group B [（5.36±1.75） points] and group C [（9.13±3.30） points]（P〈0.01）. 3The makers of three groups after treatment and during the follow-up decreased significantly compared with before treatment, the differences were statistically significant（P〈0.05）. The makers of the group A after treatment was（4.38 ±1.36） makers, which was significantly less than that of group B [（5.36±1.75） makers] and group C [（4.79±1.55） makers]（P〈0.05）. During the follow-up, the makers of the group A was（4.55±2.11） makers, which was significantly less than that of group B [（7.44±3.67） makers] and group C [（9.52±6.38） makers]（P〈0.05）. Conclusion The method of dispensing granule decoction of Enriching the Blood and Moisturizing the Intestine Granules combined with electro acupuncture in the treatment of STC has significant clinical curative effect, and it is worth of clinical application.