超声心动图对动脉粥样硬化兔左心室舒张功能的观察研究

Observe the changes of left ventricular diastolic function in atherosclerotic rabbit under echocardiography

目的利用超声心动图观察动脉粥样硬化兔左心室舒张功能的改变。方法 28只新西兰白兔被随机分为对照组、模型组,分别以普通饲料和高脂饲料喂养。12周末显微镜下观察心肌间质胶原纤维,测量胶原容积分数(CVF)。超声心动图检查测量舒张功能指标。结果与对照组相比,模型组心肌胶原纤维增多、增粗、排列紊乱,胶原容积分数增高。超声心动图检查:Ea降低,E/Ea增高(P<0.01),两组比较E/A差异无统计学意义(P>0.05)。结论高脂所致的动脉粥样硬化兔存在一定程度的心肌纤维化及左室舒张功能减退,超声心动图E/Ea能较灵敏地反映这种变化。

Objective We observed the changes of left ventricular diastolic function in atherosclerotic rabbits under echocardiography. Methods 28 New Zealand white rabbits were randomly divided into control group and model group. The rabbits were feed with normal diet and high fat diet respectively for 12 weeks. The change of collagen fibers in myocardial tissue was observed by microscope and the collagen volume fraction was measured. The diastolic function parameters were measured by echocardiography. Results Compared to the control group, the myocardial collagen fibers increased and thickened and getting disorganized and collagen volume fraction increased in the model group. The doppler index of Ea reduced and E/Ea increased （ P 〈 0.01 ）. There was no statistically significant differences of E/A between the two groups （ P 〉 0. 05 ）. Conclusions In the rabbit model of atherosclerosis, there exist myocardial fibrosis at certain degree and left ventricular diastolic function reduction, fortunately E/Ea can reflect these changes sensitively.