维生素D_2磷葡钙联合卡托普利治疗高血压病的疗效分析

Analysis of therapeutic effect of vitamin D_2 phosphate glucose calcium combined with captopril in treatment of hypertension

目的观察维生素D2磷葡钙联合卡托普利治疗高血压病的治疗效果,为临床治疗高血压病提供参考依据。方法对确诊为高血压病的患者随机分成对照组与治疗组,对照组使用卡托普利口服治疗,治疗组在使用卡托普利治疗的基础上加用维生素D2磷葡钙口服治疗。治疗4周后,评价治疗有效率、血压下降情况及不良反应发生的情况。结果治疗组有效率明显高于对照组,两组相比较差别有统计学意义(P<0.05);两组平均收缩压、平均舒张压均明显下降,但两组相比较差别无统计学意义(P>0.05);治疗组不良反应发生率较对照组低,二者相比较差别有统计学意义(P<0.05)。结论维生素D2磷葡钙联合卡托普利治疗高血压病优于卡托普利,且不良反应发生率低,在临床中可推广应用。

Objective We aimed to observe the therapeutic effect of vitamin D2 phosphate glucose calcium combined with captopril in treatment of hypertension, in order to provide the reference for the clinical treatment of hypertension. Methods The patients who were diagnosed as hypertension were divided into control group and treatment group randomly. Patients in the control group taken captopril orally, while patients in treatment group were given vitamin D2 phosphate glucose calcium combined with captopril. Therapeutic efficiency and decrease of blood pressure and occurrence of adverse reaction were evaluated four weeks after the treatment. Results The effective rate of treatment group was obviously higher than that of control group, the difference was statistically significant （P 〈 0. 05 ）. Mean systolic blood pressure and diastolic pressure in both groups were significantly decreased, but the difference between the two groups was not statistically significant （ P 〉 0. 05 ）. The difference of incidence of adverse reactions between the two groups was statistically significant （ P 〈 0. 05 ）, and the occurrence rate of adverse reactions in treatment group was lower than that of control group. Conclusions The efficacy of Vitamin D2 phosphate glucose calcium combined with captopril is better than use captopril only in the treatment of hypertension for its low incidence of adverse reactions, so it can be popularized in clinical application.