比较阿昔洛韦与更昔洛韦治疗单纯疱疹性角膜炎的疗效和安全性

Comparison on the efficacy and safety of acyclovir and ganciclovir in the treatment of herpes simplex keratitis

目的比较阿昔洛韦与更昔洛韦治疗单纯疱疹性角膜炎的疗效和安全性。方法将2012年3月至2013年8月我院80例单纯疱疹性角膜炎患者,随机分为两组,每组40例。两组均给予常规抗炎以及抗病毒治疗,对照组另给予阿昔洛韦治疗,观察组则给予更昔洛韦治疗,比较两组症状改善情况及治疗有效率。结果观察组总有效率为95%,明显高于对照组的82.5%(P<0.05);观察组眼部症状及角膜病变改善程度评分,明显优于对照组(P<0.05);观察组不良反应发生率及复发率,明显低于对照组(P<0.05)。结论更昔洛韦治疗单纯疱疹性角膜炎疗效确切,可在短时间内缓解患者症状与临床体征,不良反应少,不易复发,与阿昔洛韦相比更具治疗优势,值得推广应用。

Objective We were to compare the efficacy and safety of acyclovir and ganciclovir in the treatment of herpes simplex keratitis. Methods Eighty cases of patients with herpes simplex keratitis, hospitalized in our hospital during March 2012 and August 2013, were randomly divided into two groups, 40 cases in each group. Patients in both groups were given conventional anti - inflammatory and anti - viral treatment. It was different that patients in the control group received the treatment of acyclovir, while patients in observation group were given ganciclovir. The improvement of symptoms and efficiency of the two groups were compared. Results The total effective rate of observation group was 95% and significantly higher than that of control group （82.5%,P 〈 0. 05）. The improvement of ocular symptoms and corneal lesions of observation group were better than the control group （P 〈 0. 05）. The incidence of adverse reactions and recurrence rate of observation group were lower than the control group （P 〈 0. 05 ）. Conclusions Ganciclovir is better than acyclovir in treating herpes simplex keratitis, it can relieve symptoms and clinical signs in a short time with fewer adverse reactions and less easily to relapse, so it worthy of promotion and application.