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过氧化物酶体增殖物激活受体-γ与非酒精性脂肪肝及2型糖尿病 被引量:1

Correlation of peroxisome proliferator-activated receptor γ with nonalcoholic fatty liver disease and type 2 diabetes mellitus
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摘要 非酒精性脂肪肝(NAFLD)和2型糖尿病已成为危害人类健康的重要问题。胰岛素抵抗可能是2型糖尿病与NAFLD的共同机制。过氧化物酶体增殖物激活受体(PPAR)-γ是联系两者的桥梁。本文主要讨论PPAR-γ与NAFLD和2型糖尿病的关系以及选择性PPAR-γ调节剂(SPPARM)的临床研究进展。 Nonalcoholic fatty liver disease(NAFLD) and type 2 diabetes have become a harmful problem to human health. Usually, the pathogenesis of type 2 diabetes and NAFLD is insulin resistance. However, the peroxisome proliferatoractivated receptor(PPAR)-γ is a bridge to link these two diseases. This review mainly discusses the correlation of PPAR-γwith NAFLD and type 2 diabetes, and describes the clinical research progress of selective PPAR-γ modulators(SPPARM).
作者 仓桢 王宁荐
出处 《世界临床药物》 CAS 2015年第3期151-154,共4页 World Clinical Drug
关键词 过氧化物酶体增殖物激活受体(PPAR)-γ 2型糖尿病 非酒精性脂肪肝(NAFLD) 选择性PPAR-γ调节剂(SPPARM) peroxisome proliferator-activated receptor(PPAR)-γ type 2 diabetes mellitus nonalcoholic fatty liver disease(NAFLD) selective PPAR-γ modulator(SPPARM)
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