应用6%纳米二氧化硅改性氰基丙烯酸酯抗菌胶的抗菌性研究

An Antimicrobial Study on Cyanoacrylate Antimicrobial Adhesive Modified by 6% Nano-silica

目的研究应用6%纳米二氧化硅改性氰基丙烯酸酯抗菌胶的抗菌性能。方法采用滤纸片法测试6%纳米二氧化硅/抗菌胶对金黄色葡萄球菌(ATCC29213)的抑菌性能,以未改性的抗菌胶作为对照,测量抑菌圈直径。制作大鼠外伤动物模型,分别用6%纳米二氧化硅抗菌胶及纱布包扎处理伤口,观察伤口的大体情况,并做动脉血常规及创面组织病理切片检测白细胞计数。结果 6%纳米二氧化硅/抗菌胶组第5天的抑菌圈直径为(28.61±0.91)mm,抗菌胶组为(28.24±2.69)mm,两组比较差异无统计学意义(P>0.05)。动物实验方面,在血常规及创面组织病理切片中,6%纳米二氧化硅/抗菌胶处理创面的感染情况均低于纱布包扎组(P<0.05)。结论 6%纳米二氧化硅改性的抗菌胶具有较好的抗菌性能(抗金黄色葡萄球菌)。

Objective To study the antimicrobial function of Cyanoacrylate antimicrobial adhesive modified by modified. Methods Antimicrobial function to staphylococcus aureus（ ATCC29213） of cyanoacrylate antimicrobial adhesive modified 6% nano-silica was examined with filter paper method,while unmodified antimicrobial adhesive was used as a control group,and the diameter of the inhibition zone was detected. The rat models of external injury were established,and then the wounds were treated with 6% nano-silica antimicrobial adhesive and gauze bandage respectively.The general conditions of wounds were observed,and routine blood tests and pathological sections were performed to calculate white blood cell count（ WBC）. Results The diameter of inhibition zone in antimicrobial adhesive modified 6%nano-silica group on 5thd after treatment was（ 28. 61 ± 0. 91） mm,while the diameter in control group was（ 28. 24 ±2. 69） mm,but the difference was not statistically significant（ P〈0. 05）. The blood routine tests and pathological sections showed that 6% nano-silica or antimicrobial adhesive had a lower infection rate than that by gauze bandage（ P〈0. 05）. Conclusion The Cyanoacrylate antimicrobial adhesive modified by 6% nano-silica has a good antimicrobial function（ resistant staphylococcus aureus）.