5-氨基酮戊酸光动力联合CO_2激光治疗老年尖锐湿疣临床疗效观察

Clinical Effect of 5-aminolevulinic Acid Photodynamic Therapy Combined with Carbon Dioxide Laser on Condyloma Acuminatum in Senile Patients

目的探讨5-氨基酮戊酸光动力疗法(5-aminolevulinic acid photodynamic therapy,ALA-PDT)联合CO2激光治疗老年尖锐湿疣的临床疗效。方法选择我院就诊的60例老年尖锐湿疣患者,随机分为治疗组和对照组各30人,对照组仅采用CO2激光去除疣体;治疗组用CO2激光去除疣体,用20%ALA溶液沿疣体周围2cm外敷创面,薄膜封包3小时后用光动力治疗仪距离患处15cm照射20分钟,每周1次,连续3周。治疗结束后两组患者均随访6个月。结果治疗组完成随访27例,对照组完成随访29例。治疗组治愈率为70.37%,对照组治愈率为37.93%,两组治愈率差异具有统计学意义(P<0.05)。结论 5-氨基酮戊酸光动力联合CO2激光治疗老年尖锐湿疣治愈率高,复发率低。

Objective To discuss the clinical effect of 5-aminolevulinic acid photodynamic therapy（ALA-PDT） combined with carbon dioxide laser on condyloma acuminatum in senile patients. Methods 60 senile out-patients with condyloma acuminatum were selected and divided randomly into 2 groups： treatment group and control group, 30 in each; carbon dioxide laser was applied in removing the warts of the patients in both groups while ALA-PDT was added to patients in treatment group： external application of 20% ALA liquid was made on the lesions and the round area within 2cm and the lesions were covered with occlusive film for 3 hours, and then were irradiated by Photodynamic Therapeutic Apparatus with a distance of 15 cm from the lesions for 20 minutes, once a week, 3 times in total;follow-up lasted from 6 months in both group. Results 27 patients in treatment group received follow-up while 29 in control group; the cure rate in treatment group was 70.37% while 37.93% in control group, the difference was of statistical significance（P〈0.05）. Conclusions 5-aminolevulinic acid photodynamic therapy（ALA-PDT） combined with carbon dioxide laser is of high cure rate and low reoccurrence in the treatment of condyloma acuminatum in senile patients.