骨折术后患者应用活血化瘀类药物促进骨折愈合的近期与远期疗效

Postoperative Short-Term and Long-Term Effect on Promoting Healing Fracture of Fracture Patients Treated with Activating Blood Circulation and Resolving Stasis Drugs

目的:探讨骨折术后患者采用中医活血化瘀类药物进行治疗的近期及远期疗效,为临床上骨折患者的康复治疗提供指导建议。方法:随机将我院骨科收治的56例骨折手术复位患者分成治疗组和对照组各28例,对照组采用常规手术复位后康复治疗措施:抗感染、镇痛及康复训练;治疗组在上诉基础上加用中医活血化瘀类药物(丹参酮、血塞通针);比较两组患者用药后肿胀、疼痛持续时间的差异,骨折愈合时间、功能恢复时间差异。结果:治疗组和对照组第3、5、7天的疼痛VAS评分结果,治疗组的疼痛评分均明显低于对照组,且两组间差异具有统计学意义(P<0.05);治疗组和对照组的肿胀程度比较,治疗前两组肿胀程度分级分布差异不具有统计学意义(P>0.05),具有可比性两组;治疗后1周,两组的肿胀分级,治疗组的肿胀1级患者明显高于对照组,3级患者明显低于对照组,且差异具有统计学意义(P<0.05);治疗组的治愈率为86%,对照组为79%,两组治愈与好转(删去未愈组)比较,差异不具有统计学意义(P>0.05),两组骨折愈合结果无差异。骨折愈合时间治疗组为(28.5±1.25)周明显低于对照组的(35.5±2.5)周,且差异具有统计学意义(P<0.05);两组骨折愈合后不适情况发生率治疗组为3.57%,对照组为21.42%,对照组明显高于治疗组,差异具有统计学意义(χ2=4.082,P=0.043<0.05)。结论:骨折术后患者采用中医活血化瘀类药物进行治疗对骨折愈合结果虽然没有明显影响,但是可以减少愈合时间、降低疼痛及肿胀程度。

Objective： To investigate short-term and long-term effect of the fracture treated with traditional Chinese medicine drugs for activating blood and resolving stasis to provide the guidance for clinical treatment of patients with fracture. Methods： 56 cases of fracture patients in the Department of Orthopedics in our hospital were divided into treatment group and control group with28 cases in each group. The control group used the conventional rehabilitation after operation： anti infection,easing pain and rehabilitation training. The treatment group added traditional Chinese medicine drugs for activating blood and resolving stasis（tanshinone or Xueshuantong injection）. The duration of swelling and pain,the healing time of fracture and the recovery time were compared between two groups after treatment. Results： On 3. 5 and 7 d,the treatment group＇ s pain VAS score was significantly lower than that of the control group with statistical significance（P〈0. 05）. The degree of swelling in the treatment group and the control group before treatment had no statistical significance（P〉0. 05）. 1 week after treatment,treatment group＇s 1-level swelling patients were significantly more than that in control group and 3-level swelling patients were significantly fewer than that in the control group and the difference was statistically significant（P〈0. 05）. The cure rate in treatment group was 86% and that in the control group was 79% and the difference was not statistically significant（P〉0. 05）. Two groups showed no differences in fracture healing. The healing time of treatment group was 28. 5 ± 1. 25,significantly lower than 35. 5 ± 2. 5 in the control group and the difference was statistically significant（P〈0. 05）. Conclusion： After treated by promoting blood circulation and resolving blood stasis drugs,fracture healing is not promoted obviously,but it can reduce the healing time and reduce the pain and swelling.