槲皮素的降压作用及其机制研究

Antihypertensive effects and mechanisms of quercetin

槲皮素是一种天然多酚黄酮类化合物,富含于苹果、洋葱、浆果等食物中,与心血管疾病负相关。最近动物和人类试验均表明,槲皮可以降低高血压个体的血压,机制可能涉及抗氧化应激、抑制血管紧张素转化酶(ACE)活性,以内皮依赖性和非依赖性方式改善血管内皮功能等。本综述将系统阐述槲皮素的降压作用及其相关机制。

Quercetin,a natural polyphenolic flavonoid found in plant,such as apples,onions and berries,is inversely related to cardiovascular disease.Recent work using hypertensive animals and humans indicates a decrease in blood pressure after quercetin supplementation.A number of proposed mechanisms may be responsible such as antioxidant effects,inhibition of angiotensin-converting enzyme activity,and improved endothelium-dependent and-independent function.The purpose of this review is to examine the evidence supporting the role of quercetin as a potential therapeutic agent and the mechanisms by which quercetin might exert its blood pressure-lowering effect