血清降钙素原在慢性阻塞性肺疾病急性加重期患者细菌感染诊断中的意义

Clinical significance of serum procalcitonin in patients with acute exacerbation of chronic obstructive pulmonary disease

目的 探讨血清降钙素原（PCT）对慢性阻塞性肺疾病急性加重期（AECOPD）患者细菌感染的临床诊断价值.方法 入选2013年10-12月山西医学科学院山西大医院呼吸科收治的120例AECOPD患者,根据痰培养结果分为细菌感染组（48例）和非细菌感染组（72例）.收集患者白细胞计数（WBC）、血清C反应蛋白（CRP）、PCT和胸部CT的检测结果,比较各项指标阳性率.结果 细菌感染的AECOPD患者PCT检查阳性率较WBC及胸部CT检查高,差异有统计学意义[75.0％ （36/48）比58.3％ （28/48）、52.1％（25/48）,P＜0.05].结论 PCT对判断AECOPD患者细菌感染有参考价值,对抗菌药物的使用有指导意义.

Objective To explore the clinical value of the serum procalcitonin （PCT） on diagnosis of bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Totally 120 AECOPD patients in Shanxi Dayi Hospital of Shanxi Academy of Medical Sciences from October 2013 to Decenber 2013 were retrospectively analyzed. According to the results of sputum culture, the patients were divided into bacterial infection group（48 cases） and non-bacterial infection group（72 cases）. The counts of white blood cell ,serum level of C reactive protein （CRP）procalcitonin level and the results of chest CT were analyzed. Results In patients with bacterial inictions, the positive rate of serum PCT was higher than that of white blood cell counts and CT findings, with statistical differences [75.0% （36/48） vs 58.3% （28/48）, 52.1% （25/48）, P 〈0.05]. Conclusion Procaleitionin level can be valuable for diagnosis of bacterial infection in AECOPD.