脑血疏口服液治疗大面积脑梗死临床效果观察

Efficacy of Naoxueshu in treatment of massive cerebral infarction

目的 观察脑血疏口服液治疗大面积脑梗死的临床疗效.方法 将50例大面积脑梗死患者完全随机分成观察组（25例）和对照组（25例）.2组均给予抗血小板聚集、调脂、脱水降颅压、清除氧自由基、营养神经、控制血压血糖、保护胃黏膜、维持水电解质平衡等综合治疗措施及神经康复治疗,观察组加用脑血疏口服液,疗程均为30 d.比较2组患者治疗前后美国国立卫生院神经功能缺损评分量表（NIHSS）评分及临床疗效.结果 治疗前和治疗后第3、7、14、30天,观察组NIHSS评分分别为（24.2±1.2）、（23.6±1.0）、（21.1±0.8）、（18.4±0.7）、（14.2±1.0）分,对照组NIHSS评分分别为（23.8±1.4）、（23.7±0.7）、（22.5±0.9）、（20.5±0.8）、（18.4±1.0）分.治疗后第14、30天,观察组NIHSS评分低于治疗前与对照组,差异有统计学意义（P＜0.05）.治疗1个疗程后,观察组基本痊愈5例,显著进步10例,进步6例,无变化2例,恶化2例;对照组基本痊愈3例,显著进步5例,进步5例,无变化8例,恶化4例.观察组有效率高于对照组[84.0％ （21/25）比52.0％（13/25）],差异有统计学意义（P＜0.05）.2组患者在治疗期间均未出现明显药品不良反应.结论 脑血疏口服液可改善大面积脑梗死患者神经功能缺损症状,有较好的临床疗效.

Objective To explore the clinical efficacy of Naoxueshu in treatment of massive cerebral infarction. Methods Totally 50 patients with massive cerebral infarction were randomly divided into observation group （25 cases） and control group （25 cases）. Both the two groups were given comprehensive treatment, including anti-platelet, reducing blood lipid, lowering intracranial pressure, scavenging free radical, protecting cerebral, controlling blood glucose and blood pressure, protecting gastric mucosa, balancing water and electrolyte, and nerve rehabilitation therapy. Naoxueshu was orally administrated in observation group additionally. The United States National Institutes of Health Stroke Scale （NIHSS） score before and after treatment was assessed, and the clinical efficacy was compared between the two groups. Results Before treatment and 3,7, 14 and 30 days after treatment, the NIHSS score was （24.2 ± 1.2）, （23.6 ± 1.0）, （21.1 ±0.8）, （ 18.4 ±0.7）, （ 14.2 ± 1.0） in observation group ; it was （ 23.8 ± 1.4）, （ 23.7 ± 0.7 ）, （ 22.5 ± 0.9 ）, （ 20.5 ± 0.8 ）, （ 18.4 ± 1.0） in control group. The NIHSS score in observation group was statistieally lower than that of control group 14 and 30 days after treatment （ P 〈 0.05 ）. After one eourse of treatment, there were 5 eases of complete reeovery, 10 eases of signif- icant progress, 6 cases of progress, 2 eases with no ehanges and 2 cases of deterioration in observation group; there were 3 eases of complete reeovery, 5 eases of significant progress, 5 eases of progress, 8 eases with no change and 4 eases of deterioration in eontrol group. Observation group had a higher effeetive rate than control group [ 84.0% （21/25） vs 52.0% （13/25） , P 〈 0.05 ]. No obvious adverse drug reactions occurred in both groups. Conclusion Naoxueshu can improve the cerebral infarction symptoms of massive cerebral infarction.