多靶点治疗老年肾病综合征的临床分析

Clinical analysis of multi-targets therapy in treatment of elderly nephrotic syndrome

目的探讨多靶点治疗老年肾病综合征的临床疗效。方法我院2012-05-2014-05收治的63例老年肾病综合征患者随机分为多靶点治疗组和对照组。多靶点治疗组应用强的松、吗替麦考酚酯、他克莫司联合治疗,对照组应用强的松和环磷酰胺治疗。治疗3个月后,观察各治疗组的临床表现和尿液以及血液生化指标。结果治疗3个月后,多靶点组患者的治疗总有效率为96.88%（31/32）,明显高于对照组83.87%（26/31）（P〈0.05）;多靶点组患者的尿蛋白定量、血肌酐、胆固醇以及血清白蛋白均较对照组明显改善（P〈0.05）;多靶点组患者的复发率和不良反应发生率均明显低于对照组（P〈0.05）。结论多靶点治疗老年肾病综合征的临床疗效显著。

Objective To investigate the clinical efficacy of multi-targets therapy in treatment of elderly nephrotic syndrome. Methods Sixty-three elderly nephrotic syndrome patients in our hospital from May 2012 to May 2014 were randomly divided into the multi-target group and control group. Patients in multi-target group were treated with prednisone,mycophenolate mofetil（ MMF）,tacrolimus,while patients in control group were treated with prednisone and cyclophosphamide. Clinical efficacy,urine and blood biochemical indexes were estimated after 3-month treatment. Results After 3-month treatment,the total effective rate in multi-target group was 96. 88%（ 31 /32）,significantly higher than in control group（ 83. 87%,P〈0. 05）. The urinary protein,serum creatinine,cholesterol and serum albumin were significantly improved in multi-target group compared with control group（ P〈0. 05）. The recurrence rates and incidences of side effects were significantly lower in multi-target group than in control group（ P〈0. 05）. Conclusion The clinical efficacy of multi-targets therapy in treatment of elderly nephrotic syndrome is significant.