CD_(44v6)在乳腺癌中的表达及其临床意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF CD_(44v6) IN BREAST CANCER

目的 :探讨 CD4 4v6 在乳腺癌中的表达及其临床意义。方法 :应用免疫组织化学 S- P法分别检测 CD4 4v6 在 5例正常乳腺组织和 6 4例乳腺癌组织中的表达 ,分析它的表达与乳腺癌临床病理因素的关系。结果 :CD4 4v6 在正常乳腺导管上皮细胞和腺泡上皮细胞呈阴性表达 ,而在肌上皮细胞呈强阳性表达 ;CD4 4v6 表达和淋巴结有无转移、ER、PR有关 (P<0 .0 0 1和 P<0 .0 5 ) ,CD4 4v6 表达阴性患者 5年生存率高于阳性者 ,差异有显著性意义 (P<0 .0 5 ) ,而与患者年龄、月经状态、肿瘤大小、TNM分期、组织学类型、组织学分级无关。结论 :CD4 4v6 在乳腺癌浸润和转移中可能起重要作用 。

Objective:To investigate the expression and clinical significance of CD 44v6 in breast cancer.Methods:We studied each expression of CD 44v6 ,and the relationship between each expression and clinico pathological factors in human breast cancer by immunohisto chemistry using anti CD 44s and anti CD 44v6 monoclonal antibodies in 64 female breast cancer specimens and 5 normal tissue specimens.Results:In normal breast tissues,luminal epithelial cells were negative for CD 44v6 investigated in contrast to myoepithelial cells strong staining.CD 44v6 expression in tissue sections was showed to be significantly related with lymph node status, ER, PR( P <0.001 and P <0.05 respectively). Patients with CD 44v6 negative tumors had higher five year survival rate than that of those with CD 44v6 positive tumors( P <0.05). No significant associations were found between the expression of CD 44v6 and patients′age, menopausal status, tumor size,TNM stage,histology and histological grading.Conclusion:CD 44v6 expression may play important role in infiltration and metastasis of human breast cancer and may be as a prognostic marker.